Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Allelic frequency of a p53 polymorphism in human lung cancer. 1302561

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE The p53 gene has been implicated as a tumor suppressor gene involved in the pathogenesis of lung cancer. 1310070

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Three of 23 mutations were nonsense mutations; to date, nonsense mutations of p53 have not been reported in lung cancer. 1312896

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Strikingly, a variety of lung cancer derived p53 mutations occurring outside this domain disrupt this activity. 1314165

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE None of these lung cancer patient sera had measurable amounts of p53 antigen. 1322237

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE None of the mutations were G:C to T:A transversions in the coding strand of the p53 gene, which are the most frequent base substitutions associated with tobacco smoking, and none were found at the hotspot codons described in lung cancer. 1347094

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan. 1348931

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Relationship of H-ras-1, L-myc, and p53 polymorphisms with lung cancer risk and prognosis. 1486864

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 PosttranslationalModification BEFREE These results indicate that mutation of the p53 tumor suppressor gene plays an important role in the development of primary lung cancer, and that nuclear accumulation of p53 protein is a potential prognostic factor in adenocarcinoma of the lung. 1544866

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE In contrast, p53 expression vectors bearing lung cancer derived mutations affecting single amino acids had lost this growth suppressing ability. 1559236

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer. 1565144

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE We conclude that there are low- and high-expression groups of p53 mutants in lung cancer and that the detection of protein expression in tumor cells by immunocytochemistry and immunoblotting is dependent upon the type of mutation of the p53 tumor-suppressor gene. 1565469

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Mutation of the p53 gene is the most frequently identified genetic change in human lung cancer; these findings suggest that simple immunohistological methods can provide strong evidence of such mutation. 1969059

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE However, the presence of p53 mutations was not significantly associated with tumor stage, nodal status or sex and was found in all histologic types of lung cancer. 1979160

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE These findings further support the role of inactivation of the p53 gene in the pathogenesis of lung cancer and indicate the role of intronic point mutation in this process. 2164047

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE The high incidence of loss of 17p (14 of 21 specimens) appears to be compatible with reports implicating the TP53 gene (at band 17p13) as a frequent site for genetic alteration in lung cancer. 2176544

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE A chemical mismatch cleavage method useful for the detection of point mutations in the p53 gene in lung cancer. 2223098

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 Biomarker BEFREE These findings, coupled with the previous demonstration of 17p allele loss in lung cancer, strongly implicate p53 as an anti-oncogene whose disruption is involved in the pathogenesis of human lung cancer. 2554494

1989

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 AlteredExpression BEFREE We have applied these methods in several applications, including detection of the p53 gene in human tumor samples, localization of insulin-like growth factor-IA mRNA in cell lines with low levels of expression, and distribution of transferrin mRNA in lung cancer cell lines and tumors. 7542678

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Previous studies of the mutational spectra of the p53 gene in lung cancer have shown cigarette smoke and radon exposure to be associated with the induction of particular lesions or classes of lesions. 7549812

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE Higher lung cancer risk for younger African-Americans with the Pro/Pro p53 genotype. 7554076

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE An association between the BstU I 1-1 (Pro-Pro) genotype of the p53 codon 72 polymorphism and lung cancer has previously been reported by Kawajiri et al. 7554081

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE The p53 gene alterations in lung cancer tissues were more frequently observed among the patients with a susceptible allele of CYP1A1 gene. 7581493

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE In lung cancer, the prevalence of p53 antibodies is high (30%) and is correlated with a very high rate of p53 mutations in this cancer (60-70%). 7585154

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.100 GeneticVariation BEFREE To gain insights into possible etiological risk factors responsible for this high incidence, we examined p53 mutations in 35 lung cancer specimens from Chinese females living in Hong Kong and compared them with 35 matched cases from Japanese women as well as previously reported p53 mutations in the world literature. p53 mutations in exons 5-8 were present in 20 and 31% of the Hong Kong and Japanese cases, respectively. 7585600

1995