Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE In this study, we confirm that PTEN mutations in sporadic thyroid cancer are infrequent as we found one point mutation and one heterozygous deletion of PTEN gene in 26 tumors and eight cell lines screened. 10918569

2000

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Strong correlations (0.68 ≤ r ≤ 1.0) were observed between PIK3C3 and PIM3 in breast cancer, between PIK3C3 and PTEN in breast and ovary cancers, and between PIM3 and PTEN in breast, kidney, liver, and thyroid cancers during disease progression, implicating that the correlations for cancer network gene expressions could serve as a supplement to current clinical biomarkers, such as cancer antigens, for early cancer diagnosis. 24818135

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE We show here that adenosine triphosphate (ATP) regulates PTEN subcellular localization in a variety of different cancer cell lines, including those derived from breast, colon and thyroid carcinomas. 18579579

2008

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline PTEN mutations cause 85% of Cowden syndrome (CS), characterized by a high risk of breast and thyroid cancers, and 65% of Bannayan-Riley-Ruvalcaba syndrome (BRRS), characterized by lipomatosis, hemangiomas and speckled penis. 17405772

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE 1alpha,25-Dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesiveness. 15890670

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE In conclusion, our data define a novel mechanism of PI3K/AKT hyperactivation and outline a regulatory role for miR-146b in suppressing PTEN expression, a frequent observation in thyroid cancer. 29353884

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Sequencing of tumor tissue revealed a second hit in PTEN in the thyroid carcinoma and VC, confirmed by a PTEN loss and activation of the PI3K/AKT pathway in immunohistochemistry. 30111295

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE At the present time, no study has been undertaken to consider thyroid cancer treatment via FOXOs and PTEN targeting. 26597586

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Overall, our results suggest that PTEN can function as an important modulator of extracellular matrix proteins in thyroid cancer. 15707585

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE PTEN knockdown in thyroid cancer cell lines stabilized intracellular NIS protein by promoting an interaction with NIS-LARG (leukemia-associated RhoA guanine exchange factor). 30217930

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Notably, individuals with SDH(var+) alone had the highest thyroid cancer prevalence (24/47) compared with PTEN(mut+) patients (27/105, P = 0.002) or PTEN(mut+)/SDH(var+) carriers (6/22, P = 0.038). 21979946

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE The latter could explain the clinically observed decrease in thyroid cancer prevalence in patients with co-existent PTEN mutations and SDHx variants. 28164237

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE The transcriptional silencing of PTEN was significantly associated with the anaplastic subtype, suggesting that PTEN is involved in the carcinogenesis of highly malignant or late-stage thyroid cancers, whereas this particular mechanism appears to be of minor importance in differentiated follicular thyroid tumors. 12203792

2002

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. 9140396

1997

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer. 26106610

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline phosphatase and tensin homolog (PTEN) mutations cause Cowden syndrome (CS), associated with breast and thyroid cancers. 20600018

2010

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE Our study shows that low blood PTEN protein expression could serve as a screening molecular correlate to predict for germline PTEN mutation in CS and CS-like presentations of thyroid cancer. 23066114

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE A total of 32 of 225 PTEN mutation+ patients (14%) had thyroid cancer: 52% papillary, 28% follicular-variant papillary, 14% follicular, and 6% anaplastic. 23158187

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE We show that SRC inhibition could rescue SDHD dysfunction-induced cellular phenotype and tumorigenesis only when wild-type PTEN is expressed, in thyroid cancer lines. 25149476

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Mutations in BRAF, NRAS, KRAS and PTEN, that are known to be involved in thyroid cancer biology, were detected in seven FNA samples. 24834793

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 PosttranslationalModification BEFREE PTEN promoter methylation in sporadic thyroid carcinomas. 16487009

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline mutations in the PTEN gene, which cause Cowden syndrome, are known to be one of the genetic factors for primary thyroid and breast cancers; however, PTEN mutations are found in only a small subset of research participants with non-syndrome breast and thyroid cancers. 26699384

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Our results suggest that downregulation of PTEN expression at the mRNA level plays a role in PTEN inactivation in thyroid cancer and PTEN exerts its tumour-suppressive effect on thyroid cancer through the inhibition of cell cycle progression alone or both cell cycle progression and cell death. 11159944

2001

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE Whereas PTEN inactivation is uncommon in sporadic thyroid cancer, activation of growth factor pathways that signal through Akt is frequently identified. 11507060

2001

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GenomicAlterations CGI