Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GenomicAlterations CGI

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 CausalMutation CGI

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker HPO

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. 9140396

1997

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE We have shown that germline mutations of PTEN are present in individuals with two hamartoma syndromes: Cowden Syndrome, associated with a predisposition to breast and thyroid cancers, and Bannayan-Zonana syndrome. 9620558

1998

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden syndrome (CS), which is characterized by a high risk of breast and thyroid cancers. 10514407

1999

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE PTEN mutations have been implicated in the development of a variety of human neoplasia, including high-grade glioblastoma, prostate, breast, endometrial, and thyroid carcinoma. 10910075

2000

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE In this study, we confirm that PTEN mutations in sporadic thyroid cancer are infrequent as we found one point mutation and one heterozygous deletion of PTEN gene in 26 tumors and eight cell lines screened. 10918569

2000

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline mutations in PTEN cause Cowden syndrome (CS), which is characterized by multiple hamartomas and a high risk of breast and thyroid cancers. 11021816

2000

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Our results suggest that downregulation of PTEN expression at the mRNA level plays a role in PTEN inactivation in thyroid cancer and PTEN exerts its tumour-suppressive effect on thyroid cancer through the inhibition of cell cycle progression alone or both cell cycle progression and cell death. 11159944

2001

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE Whereas PTEN inactivation is uncommon in sporadic thyroid cancer, activation of growth factor pathways that signal through Akt is frequently identified. 11507060

2001

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE The transcriptional silencing of PTEN was significantly associated with the anaplastic subtype, suggesting that PTEN is involved in the carcinogenesis of highly malignant or late-stage thyroid cancers, whereas this particular mechanism appears to be of minor importance in differentiated follicular thyroid tumors. 12203792

2002

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE We believe this to be the first demonstration of LAR overexpression in thyroid carcinoma and may help to elucidate the role of PTPases in the development of malignancy. 12698188

2003

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Moreover, germline mutation of PTEN leads to the development of the related hereditary cancer predisposition syndromes, Cowden disease, and Bannayan-Zonana syndrome, wherein breast and thyroid cancer incidence is elevated. 15254063

2004

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Overall, our results suggest that PTEN can function as an important modulator of extracellular matrix proteins in thyroid cancer. 15707585

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE 1alpha,25-Dihydroxyvitamin D3 targets PTEN-dependent fibronectin expression to restore thyroid cancer cell adhesiveness. 15890670

2005

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE PTEN, a dual-phosphatase tumor suppressor, is inactivated in Cowden syndrome (CS), characterized by high risk of breast and thyroid cancer, and in variety of sporadic cancers. 16436456

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 PosttranslationalModification BEFREE PTEN promoter methylation in sporadic thyroid carcinomas. 16487009

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline PTEN mutations cause 85% of Cowden syndrome (CS), characterized by a high risk of breast and thyroid cancers, and 65% of Bannayan-Riley-Ruvalcaba syndrome (BRRS), characterized by lipomatosis, hemangiomas and speckled penis. 17405772

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE We show here that adenosine triphosphate (ATP) regulates PTEN subcellular localization in a variety of different cancer cell lines, including those derived from breast, colon and thyroid carcinomas. 18579579

2008

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 AlteredExpression BEFREE Because in most of the thyroid carcinomas, DeltaNp73alpha is upregulated, whereas PTEN expression down regulated, we investigated whether DeltaNp73alpha may influence PTEN expression in this cell model. 19173293

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Recent novel and promising findings include additional abnormalities in key pathways associated with thyroid tumorigenesis (RET-Ras-BRAF-MEK; RET-beta-cateinin; TRK-PI3K-AKT; and MDM-p53-PTEN), single-nucleotide polymorphisms associated with thyroid cancer susceptibility, epigenetic silencing, alternative splicing, and gene expression abnormalities. 19907326

2010

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Germline phosphatase and tensin homolog (PTEN) mutations cause Cowden syndrome (CS), associated with breast and thyroid cancers. 20600018

2010

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 GeneticVariation BEFREE Children presenting with thyroid cancer should be tested for PTEN mutations. 21956414

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.500 Biomarker BEFREE Notably, individuals with SDH(var+) alone had the highest thyroid cancer prevalence (24/47) compared with PTEN(mut+) patients (27/105, P = 0.002) or PTEN(mut+)/SDH(var+) carriers (6/22, P = 0.038). 21979946

2012