Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE P-glycoprotein was distributed over the luminal surface of the colorectal carcinoma. 1977924

1990

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE With the use of a slot blot assay, relatively low levels of MDR1 RNA were present in all four gastric carcinoma cell lines, while intermediate or high levels were present in most of the colorectal carcinoma cell lines. 1967320

1990

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE Expression of the mdr1 gene in human colorectal carcinomas: relationship with multidrug resistance inferred from analysis of human colorectal carcinoma cell lines. 1537074

1992

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE MDR1 gene expression in primary colorectal carcinomas. 8398695

1993

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE Pgp expression was not associated with either p53 expression (P = 0.73) or incidence of p53 gene mutation (P = 0.70), suggesting that mutant p53 does not induce Pgp overexpression in colorectal carcinomas. 7640210

1995

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases. 8898977

1996

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Expression of the low-density lipoprotein receptor, HMG-CoA reductase, and multidrug resistance (Mdr1) genes in colorectal carcinomas. 8678896

1996

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE MDR1 RNA transcripts do not indicate long-term prognosis in colorectal carcinomas. 9337699

1997

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE P-glycoprotein is positively correlated with p53 protein accumulation in human colorectal cancers. 9330605

1997

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE These results suggest that the mdr-1 mRNA expression in gastric and colorectal cancers is related to the degree of cellular differentiation. 9677442

1998

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE P-glycoprotein (P-gp) is a 170 kDa transmembrane glycoprotein which plays a significant role in modulating pleomorphic or multiple drug resistance (MDR) in a wide variety of human cancers like renal and colorectal carcinoma. 10630353

1999

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE The role of P-glycoprotein (MDR1) polymorphisms and mutations in colorectal cancer. 11678332

2001

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. 11323103

2001

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE AFP promoter-driven anti-MDR1 ribozymes reduced the IC(50) 30-fold for epirubicin in HCC cells, whereas human colorectal cancer cells were unaffected. 12297834

2002

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Pro-oncogenic factors that also release beta-catenin from the adherens complex and/or encourage translocation to the nucleus include ras, epidermal growth factor (EGF), c-erbB-2, PKC-betaII, MUC1, and PPAR-gamma, whereas anti-oncogenic factors that also inhibit nuclear beta-catenin signaling include transforming growth factor (TGF)-beta, retinoic acid, and vitamin D. Association of nuclear beta-catenin with the T cell factor (TCF)/lymphoid enhancer factor (LEF) family of transcription factors promotes the expression of several compounds that have important roles in the development and progression of colorectal carcinoma, namely: c-myc, cyclin D1, gastrin, cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-7, urokinase-type plasminogen activator receptor (aPAR), CD44 proteins, and P-glycoprotein. 11839557

2002

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE The resulting cell line (AMC5/B1) was 5.3-fold resistant to berberrubine in the absence of MDR1 overexpression. 11901227

2002

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE We analyzed the C3435T SNP in the MDR1 gene which is associated with altered cellular drug uptake in matched tumor and normal tissues of 45 patients suffering from colorectal carcinoma. 12894567

2003

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 PosttranslationalModification BEFREE Wide-type p53 gene has a remarkable reversal activity for the high expression of MDR1 gene in colorectal cancers. 15222051

2004

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE TAM can reverse the MDR of colorectal carcinoma in nude mice, which is independent of the expression of ER; however, no change was observed in the expressive level of mdr1 mRNA. 15742416

2005

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans. 16800822

2006

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. 16702732

2006

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE However, a smoking and age-stratified analysis, revealed a statistically significant association between MDR1 genotypes and colorectal cancer in life-long non-smokers with an age > or =63 years (the median age in our sample). 17146660

2007

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE In the present study, 146 Bulgarian patients with sporadic colorectal cancer and 160 healthy Bulgarian volunteers were evaluated for the two polymorphisms in MDR1. 17674045

2008

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE The present study provides additional evidence for the role that the MDR1/ABCB1 gene plays in the initiation and progression of MSI-H CRC development. 18474294

2008

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Differences in ABCB1 (1236C>T) and ABCB1 (2677G>T/A) genotypes and T(1236) allele distribution between investigated populations indicate significant impact of these SNPs on risk of development of colorectal cancer. 19415305

2009