Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. 30393195

2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357

2019
Entrez Id: 7100
Gene Symbol: TLR5
TLR5
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human TLR5 silencing reduced hyperammonaemia-induced liver injury by inhibiting oxidative stress and inflammation responses via inactivating NF-κB and MAPK signals. 30508503

2019
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes. 30394310

2019
Entrez Id: 407000
Gene Symbol: MIR218-1
MIR218-1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats. 30125006

2018
Entrez Id: 1576
Gene Symbol: CYP3A4
CYP3A4
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 2081
Gene Symbol: ERN1
ERN1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice. 30538632

2018
Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 2494
Gene Symbol: NR5A2
NR5A2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. 29515023

2018
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 283120
Gene Symbol: H19
H19
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. 30515189

2018
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis. 29499335

2018
Entrez Id: 59343
Gene Symbol: SENP2
SENP2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human SENP2 alleviates CCl4-induced liver fibrosis by promoting activated hepatic stellate cell apoptosis and reversion. 29535048

2018
Entrez Id: 24145
Gene Symbol: PANX1
PANX1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. 29246445

2018
Entrez Id: 407037
Gene Symbol: MIR320A
MIR320A
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats. 30125006

2018
Entrez Id: 8431
Gene Symbol: NR0B2
NR0B2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner. 29943110

2018
Entrez Id: 406884
Gene Symbol: MIRLET7B
MIRLET7B
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats. 30125006

2018
Entrez Id: 406935
Gene Symbol: MIR143
MIR143
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats. 30125006

2018
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 1869
Gene Symbol: E2F1
E2F1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. 30515189

2018
Entrez Id: 407026
Gene Symbol: MIR29C
MIR29C
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. 30515189

2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury. 30515189

2018
Entrez Id: 1544
Gene Symbol: CYP1A2
CYP1A2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018