Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE The evidence suggests that T cells can produce TNF and have the potential to deliver by themselves the dual and synergistic signals of TNF/LT and IFN-gamma to target cells, a process which may be of importance in the pathogenesis of human autoimmunity. 3121358

1987

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE Tumor necrosis factor and interferon gamma: relevance for immune regulation and genetic predisposition to autoimmune disease. 1627786

1992

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE In this review we focus on the new developments in the areas of IFN gamma biochemistry and biology and pay particular attention to the IFN gamma receptor and three aspects of IFN gamma biology that are of special interest to immunologists: host defense, inflammation, and autoimmunity. 8476573

1993

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker CTD_human To further define their roles in systemic autoimmunity, IL-4 and IFN-gamma gene knockout mice were studied for susceptibility to the prototypic Th2-mediated mercury-induced autoimmunity. 9647229

1998

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Among the cytokines involved in thyroid autoimmunity interferon-gamma (IFN-gamma) plays a key role in the pathogenesis of Graves' disease. 9848715

1998

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE These findings explain the bimodal role of IFN-gamma in different models of autoimmune disease and raise questions regarding the clinical relevance of these models. 11037964

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Administration of cDNA encoding soluble IFN-gamma receptor (IFN-gamma R)/IgG-Fc fusion proteins, soluble TNF-alpha receptors, or IL-1 receptor antagonist (IL-1ra), protects against either lupus, various forms of arthritis, autoimmune diabetes, or other autoimmune diseases. 11727511

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE In addition to the pivotal role of IFNgamma in host defense, its excessive release has been associated with the pathogenesis of chronic inflammatory and autoimmune diseases. 12890422

2003

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Besides being crucial for mycobacterial control, the interferon-gamma/interleukin-12 pathway is also involved in the pathogenesis of autoimmune disease, as well as tumor development and control. 14758107

2004

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE We have studied the CA repeat polymorphisms in the first intron of IFN gamma gene in Japanese patients with GD (n = 162) and healthy control subjects without antithyroid autoantibodies or family history of autoimmune disorders (n = 133). 15068623

2004

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Besides being crucial for mycobacterial control, the IFN-gamma/IL-12 pathway is also involved in the pathogenesis of autoimmune disease as well as tumor development and control. 15661020

2005

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE Blocking the transcription of the IFN-gamma gene with kinase inhibitors might lead to the development of novel therapeutic agents for patients with aplastic anemia and other autoimmune diseases. 16434488

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Immunisation with the allogeneic LNCaP/IL-2/IFN-gamma vaccine is safe and feasible without any dose-limiting toxicity or autoimmunity. 17514769

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE These results indicate a novel immunocompetent role of epithelial cells that can produce IFN-gamma, resulting in loss of local tolerance before developing gender-based autoimmunity. 19015307

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker CTD_human Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. 19077085

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE These infiltrating autoreactive T-cells and macrophages release inflammatory cytokines including interferon-gamma in the islets, not only damaging beta-cells but also accelerating CXCL10 generation in residual beta-cells and thus further activating cell-mediated autoimmunity until all beta-cells have been destroyed. 19641142

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Interferon-gamma is a potent Th1-type cytokine and a key molecule in the pathogenesis of autoimmune diseases including lupus nephritis. 20167631

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE This analysis is integrated with the literature on the roles of IFNgamma in mediating a plethora of functions: anti-microbial responses, antigen processing, inflammation, growth suppression, cell death, tumor immunity and autoimmunity. 20036577

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE In contrast, inhibition of DP IV and APN activities selectively suppresses lymphocyte functions including proliferation and production of the T helper type (Th)1 cytokine IFN-γ, the Th17 cytokine IL-17, as well as TNF-α, and ameliorates autoimmunity in vivo. 21802166

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 AlteredExpression BEFREE The T-box transcription factor T-bet is a key regulator for the lineage commitment in CD4 Th1 cells and CD8 T cells by activating the hallmark production of interferon-γ, and its expression level is linked to autoimmune diseases. 20977921

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 AlteredExpression BEFREE These findings indicate that TGP inhibits autoimmunity in SLE patients possibly by inducing Treg cell differentiation, which may in turn be due to its ability to regulate the methylation status of the Foxp3 promoter and activate IFN-γ and IL-2 signaling. 22406048

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE We conclude that a shift in immunodominance of self-antigenic determinants of Col-V results in induction of IFN-γ and IL-17 with loss of tolerance leading to autoimmunity to Col-V, which leads to chronic lung allograft rejection. 22132895

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-γ: potential therapeutic use in autoimmune diseases. 22424783

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE A marked reduction of IL-2 was also observed for all CT relatives with autoimmunity and a lack of IFN-γ production was observed for the younger brother of the index patient, heterozygous for the polymorphism. 22809281

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE Interferon-gamma (IFN-γ) is a paracrine inhibitor of melanocytes and genetic variability due to intron 1 polymorphisms in IFNG has been reported to be associated with increased risk for several autoimmune diseases. 23777204

2013