Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Four of 10 CRCs with the alterated/mutant β-catenin staining pattern studied in depth, from 181 total CRCs from tissue microarray, had pathogenic CTNNB1 mutations. 30177831

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Constitutive canonical Wnt signaling, resulting from mutations in the adenomatous polyposis coli (APC), beta-catenin, or axin genes, has been implicated in the initiation of most human colorectal cancers (CRCs). 18488710

2008

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE Furthermore, the expression of SATB2 was positively correlated with β-catenin expression in CRC. 28887549

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE To study the effect of caffeic acid phenethyl ester (CAPE) on proliferation, cell cycle, apoptosis and expression of beta-catenin in cultured human colorectal cancer (CRC) cell line HCT116. 15996024

2005

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE (P)RR silencing was performed in human colorectal cancer cells containing constitutive activating mutations in the Wnt/β-catenin pathway. 30555158

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/β-Catenin Signaling in Human Colorectal Cancer Cells. 26660958

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Examples include papers that report integrated data generated from large-scale RNA interference screens on the Wnt/beta-catenin pathway with either genotypic or proteomic data in colorectal cancer. 19436058

2009

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE OVOL2 bound T-cell factor (TCF)4 and β-catenin, facilitating recruitment of histone deacetylase 1 to the TCF4-β-catenin complex; this inhibited expression of epithelial-to-mesenchymal transition-related genes regulated by WNT, such as SLUG, in CRC cell lines. 26619963

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE The key component of the β-catenin destruction complex glycogen synthase kinase 3β (GSK-3β), one of the major target for BIO, polyubiquitination and degradation of the main oncoprotein β-catenin in colorectal cancer (CRC). 29039496

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Microsatellite, v-Ki-Ras2 Kristen rat sarcoma viral oncogene homolog (KRAS), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), tumor protein 53 (TP53) and β-catenin status were evaluated and compared between synchronous CRC lesions in each patient. 30842178

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE Nevertheless, we failed to find any exon 3 mutation of beta-catenin gene in all 60 cases of CRC. 18365911

2008

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Here, we show that Deptor, a suppressor of mTOR, is a direct target of Wnt/β-catenin/c-Myc signaling in colorectal cancer cells. 29666061

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE We applied this method for five biomarkers (CDX2, SOX2, SOX9, E-cadherin, and β-catenin) using tissue microarrays of a Norwegian unselected series of primary colorectal cancer. 31641225

2020

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE In conclusion, beta-catenin protein dysregulation, but not k-ras mutation, appears to be required for cyclin D1 overexpression in colorectal carcinoma in vivo. 12081197

2002

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE None of the PMS2-associated CRCs contained any somatic variants in the catenin-β<sub>1</sub> gene (CTNNB1), which encodes β-catenin, whereas 14 of 24 MLH1-associated CRCs (58%) contained variants in CTNNB1. 29758216

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Collectively, our data supports DB as an inhibitor of Wnt/β-catenin/Tcf signaling pathway that may be beneficial in the CRC management. 22465936

2012

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Activation of the Wnt/β-catenin pathway occurs in the vast majority of colorectal cancers. 26398937

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 GeneticVariation BEFREE The aim of this study was to analyze the frequency of β-catenin gene mutation in patients with sporadic CRC and to determine its effect in prognosis. 25313745

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Activation of the Wnt/β-catenin pathway is frequently observed in colorectal cancers. 22460269

2012

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE Importantly, JRK expression was aberrantly elevated in 21% of colorectal cancers, 15% of breast and ovarian cancers and was associated with increased expression of β-catenin target genes and increased cell proliferation. 26455321

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE We found BaP/DSS-induced CRC may be a Wnt/β-catenin independent process. 29197069

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Our results establish MACC1 as a transcriptional target of Wnt/β-catenin signaling and suggest that DBC1 plays a key role in colorectal cancer progression through Wnt/β-catenin-MACC1 signaling axis. 30082743

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE EGFL6 promotes cell proliferation in colorectal cancer via regulation of the WNT/β-catenin pathway. 30693973

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE Most instances of colorectal cancer are due to abnormalities in the Wnt signaling pathway, resulting in nuclear accumulation of beta-catenin. beta-Catenin activates transcription of target genes primarily by associating with the T cell factor/lymphoid enhancer-binding factor (TCF/Lef) family of transcription factors. 17360646

2007

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 AlteredExpression BEFREE Obviously elevated expression of Lgr5 was observed in CRC tissues, compared to the paired nontumor tissues. mRNA expression levels of Lgr5 was positively correlated with the expression of β-catenin in CRC tissues. 24751002

2014