Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE NET gene polymorphism might be associated with the risk of T2DM whereas; eNOS gene polymorphism do not confer any risk of T2DM in North Indian Ethnic group. 31377977

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Collectively, the available data suggest that the augmentation of endothelial KLF5 expression by hyperinsulinemia may represent a novel mechanism for negatively regulating eNOS expression, and may thus help to explain for the T2DM-related endothelial dysfunction at the transcriptional level. 31049798

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE P lasma NO levels were significantly higher in retinopathy, VEGF levels were significantly lower, and TAO was significantly decreased. eNOS mRNA levels were lower in the cells of T2DM patients without retinopathy, but higher in PDR. 31422516

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Skeletal muscle biopsies from subjects with type 2 diabetes showed 50% less Cav-1 and eNOS than those from lean healthy controls. 29563255

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE The lung‑protective effects of APN globular domain (gAPN) in rats with type 2 diabetes mellitus were also investigated by measuring the oxygenation index, inflammatory cytokines, lung edema, histopathology, oxidative stress, apoptosis and the protein expression levels of phosphorylated 5'adenosine monophosphate‑activated protein kinase (p‑AMPK), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS). 29568898

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Our study gave a comprehensive insight into functional interaction between GNB3 and eNOS gene polymorphisms and suggests that the eNOS G894T and T-786C variants are strong predisposing factors of VED susceptibility within men with type 2 diabetes. 30101547

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, our results indicate that NOS3 rs869109213 polymorphism alone or in a combination with EDNRB rs10507875 polymorphism may be associated with DR in Slovenian patients with T2DM. 28817788

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles augments the risk of CVD and T2DM. 29973202

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 PosttranslationalModification BEFREE AdrKO mice exhibited reduced endothelial nitric oxide synthase (eNOS) phosphorylation (Ser1177), impaired glycosphingolipid biosynthesis, adipocytes infiltrating, and loss of T<sub>reg</sub>, and developed FP and T2DM. 28837146

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE In conclusion, overexpressed eNOS may induce SIRT1 activation, which is implied to play a protective role in Min6 cells, and eNOS may be a new therapeutic target for diseases such as type 2 diabetes. 28810642

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE (-)-Epicatechin also counteracts the negative effects that high glucose or simulated type 2 diabetes has on endothelial nitric oxide synthase function. 26993496

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Compared with that in control group, the expression of TNF-α, ET, eNOS, and CD106 was significantly upregulated in the T2DM group and the treatment group, while the expression of CD54 was increased only in the T2DM group (P < 0.05). 27323139

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM. 27192959

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Following Bonferroni correction, none of the haplotypes of eNOS were significant in T2DM. 26505452

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We aimed to evaluate whether eNOS gene single nucleotide polymorphism (Glu298Asp variant) might give a relevant contribution also to the onset of hypogonadism-associated DM. 25228279

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease. 25077953

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The aim of this study was to evaluate the CYP3A4 2 and eNOS gene mutations in a large number of T2D patients undergoing statin treatments. 24996290

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The present meta-analysis suggests that the eNOS 27VNTR (4b/4a) polymorphism potentially decreases the risk of developing DR in T2DM African individuals. 24673412

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. 23182401

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Since homozygous carriers of the NOS3 G894T variant are predicted to have decreased enzyme activity, the association between NOS3 genotype and type 2 diabetes, and possible effect modification by body mass index (BMI) were evaluated. 24278136

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The meta-analysis indicated that NOS3 gene 4b4a VNTR and G894T polymorphisms might be associated with T2DM risk. 23563728

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The 4a/4a genotype of the VNTR polymorphism for endothelial nitric oxide synthase (eNOS) gene predicts risk for proliferative diabetic retinopathy in Slovenian patients (Caucasians) with type 2 diabetes mellitus. 22311033

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Our findings, for the first time, indicate that NOS3 T allele strongly interacts with CETP B1 allele to augment the risk of CAD and T2DM in the population of Western Iran. 23157875

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Our findings do not support the hypothesis that the -786T/C, the VNTR intron 4 a/b and the 894G/T (Glu298Asp) polymorphisms in the eNOS gene play a role in the pathogenesis of diabetic retinopathy in type 2 diabetes. 22017289

2012