Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE (-)-Epicatechin also counteracts the negative effects that high glucose or simulated type 2 diabetes has on endothelial nitric oxide synthase function. 26993496

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. 16581274

2006

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with type 2 diabetes and its chronic complications. 21256614

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase gene polymorphism (G894T) and diabetes mellitus (type II) among South Indians. 22110783

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus. 22313046

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 PosttranslationalModification BEFREE AdrKO mice exhibited reduced endothelial nitric oxide synthase (eNOS) phosphorylation (Ser1177), impaired glycosphingolipid biosynthesis, adipocytes infiltrating, and loss of T<sub>reg</sub>, and developed FP and T2DM. 28837146

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of eNOS gene polymorphisms with renal disease in Caucasians with type 2 diabetes. 21255858

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the endothelial nitric oxide synthase (ecNOS) gene polymorphism with carotid atherosclerosis in type 2 diabetes. 16377020

2006

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. 23182401

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Collectively, the available data suggest that the augmentation of endothelial KLF5 expression by hyperinsulinemia may represent a novel mechanism for negatively regulating eNOS expression, and may thus help to explain for the T2DM-related endothelial dysfunction at the transcriptional level. 31049798

2019

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Compared with that in control group, the expression of TNF-α, ET, eNOS, and CD106 was significantly upregulated in the T2DM group and the treatment group, while the expression of CD54 was increased only in the T2DM group (P < 0.05). 27323139

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles augments the risk of CVD and T2DM. 29973202

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease. 25077953

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Following Bonferroni correction, none of the haplotypes of eNOS were significant in T2DM. 26505452

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. 18622262

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated in the sibling pairs and in an additional 92 unrelated African-Americans with type 2 diabetes mellitus-associated ESRD (singletons). 11071967

2000

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, of the genetic polymorphisms examined at the eNOS locus, only 27bp-VNTR appears to be a minor contributor to the variation in T2DM-related traits in Mexican Americans. 18537098

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, our results indicate that NOS3 rs869109213 polymorphism alone or in a combination with EDNRB rs10507875 polymorphism may be associated with DR in Slovenian patients with T2DM. 28817788

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE In conclusion, overexpressed eNOS may induce SIRT1 activation, which is implied to play a protective role in Min6 cells, and eNOS may be a new therapeutic target for diseases such as type 2 diabetes. 28810642

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, we described a significant association between eNOS gene polymorphisms and type 2 diabetes, suggesting a new genetic susceptibility factor for hyperinsulinemia, insulin resistance, and type 2 diabetes. 12716763

2003

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In the present study, we attempted to assess whether the T-786C polymorphism of eNOS gene is associated with endothelial dysfunction Type 2 diabetes. 16401309

2005

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In view of the variable results that have been reported for the association between eNOS gene polymorphisms and DR, the present study was designed to study the association and interaction between eNOS gene polymorphisms and the development and progression of DR in Asian Indian type 2 diabetes mellitus patients (T2DM). 23085930

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Intron 4 a/b polymorphism of the endothelial nitric oxide synthase gene is associated with both type 1 and type 2 diabetes in a genetically homogeneous population. 18486763

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Lack of association between polymorphisms of catalase, copper-zinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type 2 diabetes mellitus. 11350569

2001