Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Skeletal muscle biopsies from subjects with type 2 diabetes showed 50% less Cav-1 and eNOS than those from lean healthy controls. 29563255

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. 18622262

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with type 2 diabetes and its chronic complications. 21256614

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene have been associated with DM in cross-sectional studies, but their predictive values in glycemic progression are not known. 16919532

2006

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease. 25034973

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Since NO availability may be genetically determined, we have investigated the role of endothelial nitric oxide synthase (eNOS) gene in influencing platelet aggregability in relation to the presence (n=247) or absence (n=883) of type 2 diabetes in ACS patients. 19819117

2011

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE The lung‑protective effects of APN globular domain (gAPN) in rats with type 2 diabetes mellitus were also investigated by measuring the oxygenation index, inflammatory cytokines, lung edema, histopathology, oxidative stress, apoptosis and the protein expression levels of phosphorylated 5'adenosine monophosphate‑activated protein kinase (p‑AMPK), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS). 29568898

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE We have investigated variants of the angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin type 1 receptor (AT1R) and endothelial nitric oxide synthase (NOS3) genes for association with subclinical measures of CVD in families with Type 2 diabetes mellitus (T2DM). 16492203

2006

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease. 25077953

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We studied eNOS polymorphisms in the promoter region (T-786C), in exon 7 (Glu298Asp), and in intron 4 (b/a) in 98 controls, 68 patients with HT, 66 patients with T2DM, and 86 patients with T2DM+HT. 17306574

2007

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The aim of this study was to evaluate the CYP3A4 2 and eNOS gene mutations in a large number of T2D patients undergoing statin treatments. 24996290

2014

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the endothelial nitric oxide synthase (ecNOS) gene polymorphism with carotid atherosclerosis in type 2 diabetes. 16377020

2006

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE These results suggest that intrarenal hemodynamic abnormalities are present as a feature of the progression of nephropathy in type 2 diabetes, and that they are associated with age, duration of diabetes, decreased creatinine clearance, and blood pressure, but not with the genetic factors of the ACE and ecNOS gene polymorphism in nephropathy of type 2 diabetes. 11522715

2001

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Following Bonferroni correction, none of the haplotypes of eNOS were significant in T2DM. 26505452

2015

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 PosttranslationalModification BEFREE AdrKO mice exhibited reduced endothelial nitric oxide synthase (eNOS) phosphorylation (Ser1177), impaired glycosphingolipid biosynthesis, adipocytes infiltrating, and loss of T<sub>reg</sub>, and developed FP and T2DM. 28837146

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We show here a strong independent association between eNOS genotype and AMI in patients with T2DM. 19077211

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The 4a/4a genotype of the VNTR polymorphism for endothelial nitric oxide synthase (eNOS) gene predicts risk for proliferative diabetic retinopathy in Slovenian patients (Caucasians) with type 2 diabetes mellitus. 22311033

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Intron 4 a/b polymorphism of the endothelial nitric oxide synthase gene is associated with both type 1 and type 2 diabetes in a genetically homogeneous population. 18486763

2008

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE In conclusion, overexpressed eNOS may induce SIRT1 activation, which is implied to play a protective role in Min6 cells, and eNOS may be a new therapeutic target for diseases such as type 2 diabetes. 28810642

2017

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE (-)-Epicatechin also counteracts the negative effects that high glucose or simulated type 2 diabetes has on endothelial nitric oxide synthase function. 26993496

2016

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2. 15662218

2005

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We investigated four reported polymorphisms in the VEGF (5' UTR, promoter) and one reported polymorphism (intron 4) in the eNOS gene in Type 2 diabetes patients with (n=120) and without (n=90) retinopathy. 16636650

2006

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In the present study, we attempted to assess whether the T-786C polymorphism of eNOS gene is associated with endothelial dysfunction Type 2 diabetes. 16401309

2005

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. 23182401

2013

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Our findings, for the first time, indicate that NOS3 T allele strongly interacts with CETP B1 allele to augment the risk of CAD and T2DM in the population of Western Iran. 23157875

2012