Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells. 9054611

1997

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma. 9221853

1997

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE We analyzed the relation between phenotypic (DNA ploidy) and functional markers (S-phase cell fraction, p53, and bcl-2 protein expression) and defined their relevance on clinical outcome on a retrospective series of radically resected liver metastases from colorectal cancer. 9164212

1997

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer. 9849490

1998

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE The aim of this study was to examine the relationship between apoptosis and cell proliferation in various macroscopic types of intramucosal colorectal carcinoma in relation to the expression of p53 and bcl-2. 9823803

1998

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 GeneticVariation BEFREE Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal cancer. 9881495

1999

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE bcl-2 protein expression is associated with better prognosis in colorectal cancer. 10564391

1999

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Telomerase activity in colorectal cancer and its relationship to bcl-2 expression. 10797335

2000

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Heterodimerization of Bcl-2 and Bcl-X(L) with Bax and Bad in colorectal cancer. 11041112

2000

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE These results suggest that the exposure duration, DT, and expression of MDR-1, bcl-2 and bax each contribute to paclitaxel sensitivity of human colorectal carcinoma cells. 11052631

2000

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Evidence for post-transcriptional down-regulation of the apoptosis-related gene bcl-2 in human colorectal cancer. 10767713

2000

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE In vivo, oligonucleotide 4625 statistically significantly inhibited the growth of breast and colorectal carcinoma xenografts by 51% (95% CI = 28% to 74%) and 59% (95% CI = 44% to 74%), respectively, relative to those treated with control oligonucleotide 4626; it also reduced Bcl-2 and Bcl-xL protein levels and induced tumor cell apoptosis. 11259472

2001

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE In this article, we discuss the use of specific molecular markers, including tumor-associated glycoprotein 72 (TAG-72), carcinoembryonic antigen (CEA), and oncofetal tumor antigens (Lewis X and Y) in diagnosis and as targets for novel therapies, as well as the phenotypic expression of bcl-2, mucin antigens (MUC1 and MUC2), and nuclear accumulation of p53 in predicting the clinical outcome of patients with CRC. 11151060

2001

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Molecular staging of colorectal cancer in African-American and Caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 AND p27(kip-1). 11802199

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Immunohistochemical expression of p53, mdm-2, waf-1, and bcl-2 is similar for CAC and CRC. 11865380

2002

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. 12670866

2003

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Furthermore, rhR4 treatments led to the increased expression of Bcl-2, Bcl-XL, survivin, and matrilysin, genes associated with a poor prognosis in advanced CRC. 16401477

2006

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL. 16407826

2006

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE The positive rate of apoptosis-associated proteins (Bax, Bcl-2 and survivin) in CRC tissue was 72.50%, 51.25% and 77.50%, respectively. 17373735

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Antimycin A3, in combination with SN-38 recapitulated this phenotype in HCT 116 cells, suggesting a potential role for small molecule inhibitors of Bcl-xL/Bcl-2 in the treatment of colorectal cancer, potentially in combination with irinotecan. 17273826

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Downregulation of hypoxic BNIP3 in CRC cells was independent of the expression of other BCL-2 family members, or BNIP3L. 16799636

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. 17332927

2007

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE Antisense oligodeoxynucleotides to human superoxide dismutase 2 and/or ectopic bcl-2 overexpression avoided polyphenols and chemoradiotherapy-induced colorectal cancer elimination and showed that the mangano-type superoxide dismutase and Bcl-2 are key targets in the molecular mechanism activated by the combined application of t-PTER and QUER. 18852136

2008

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE Finally, endogenous Puma is involved in the apoptotic response of human colorectal cancer cells to the Bcl-2/Bcl-xL inhibitor ABT-737, even in conditions where the expression of Mcl-1 is down-regulated. 19380879

2009

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE The multi-marker phenotype EphB2-/Bcl-2- is an independent predictor of high-grade budding and implies increased aggressive behaviour in MMR-proficient colorectal cancer. 20716165

2010