Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE C-Met as a prognostic marker in gastric cancer: a systematic review and meta-analysis. 24223894

2013

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE MET rs40239 may serve as a prognostic biomarker in locoregional gastric cancer. 25203738

2014

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE MET-positive GCs had a very poor prognosis, with a median survival of 5.4 months and a hazard ratio of 2.126. 26033401

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE c-Met targeting in advanced gastric cancer: An open challenge. 26049023

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE MET amplification has been clinically credentialed as a therapeutic target in gastric cancer, but the molecular mechanisms underlying sensitivity and resistance to MET inhibitors are still not well understood. 28881678

2017

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE MET amplification and Met overexpression were positively correlated in GC. 29790169

2018

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE A multivariate analysis suggested that MET positivity may still be prognostic for worse median overall survival in gastric cancer; therefore, it is important to continue investigation into the optimal approach to inhibit MET signaling in gastric cancer. 27401892

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer. 30511201

2019

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Also, the prognostic role of MET indicates that anti-MET therapy is a very promising modality in adjuvant treatment for gastric cancer. 22644302

2012

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Approximately 10 - 20% of gastric cancer presented an increased MET gene copy numbers; inappropriate activation of MET promotes cellular proliferation, cell motility, invasiveness and angiogenesis and is associated with more aggressive phenotype and with a lower survival. 25881479

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer. 12620387

2003

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Comprehensive genomic profiling of GC identifies clinically relevant GAs that suggest benefit from targeted therapy including MET-amplified GC and ERBB2 base substitutions. 25882375

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Crizotinib may induce clinically relevant anticancer effects in MET-overexpressed or MET-amplified gastric cancer patients. 26404902

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer. 27185371

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Exposure-response analysis of rilotumumab in gastric cancer: the role of tumour MET expression. 25584489

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Expression of gastrin and c-met protein was associated (P<0.01), but no significant difference was found on the changes of gastrin, c-met and c-erbB2 expression in gastric cancer with tumor stage, grade of differentiation or tumor type. 14719064

2004

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Finally, we observed an inverse correlation between the expression of miR-144 and MET mRNA in GC metastatic tissues. 25927670

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Four c-MET inhibitors were tested to elucidate the dependency on MET pathway in the 49 GC cell lines. 29435981

2018

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Furthermore, the profile of the gastric cancer samples observed that sf-RON was frequently upregulated in MET-positive gastric cancer. 26528757

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target. 21424128

2011

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation. 27437872

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE In 123 cases with primary and corresponding local recurrent/distant metastatic GC, 3 (2.4%) showed MET positivity in which 2 (66.7%) were discordant (positive conversion). 28968267

2018

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE In conclusion, miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K (phosphoinositide 3-kinase)/Akt pathway. 24837198

2014

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE In conclusion, miR‑34a was associated with the clinicopathological features of gastric cancer and was a valuable predictor of patient prognosis. miR‑34a acted as a tumor suppressor to inhibit gastric cancer proliferation and invasion via the downregulation of MET. 26238271

2015

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE In the present study, we identified three frequently amplified genes from 30 candidate genes using real-time quantitative PCR method, including ERBB4, C-MET and CD44, and further explored their association with clinicopathological characteristics and poor survival in a cohort of gastric cancers. 22606006

2012