Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation BEFREE To further define the role of PTEN/MMAC1 in the development of prostate cancer and its spectrum of genetic alterations, we analysed 40 pT2 or pT3 prostate tumors for allelic loss, mutations, and homozygous deletions using PCR-based methods. 9788441

1998

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. 25007053

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE We have quantitatively analyzed the mRNA levels of TMPRSS2-ERG, ERG, PTEN, and AR (n = 83), as well as ERG immunostaining (n = 78) in a series of prostate tumors. 25939480

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN-deficient mice). 29051161

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE The PTEN gene, located on 10q23, has recently been implicated as a candidate tumor suppressor gene in brain, breast and prostate tumors. 9331072

1997

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumor spheroid maintenance, whereas AKT1 is dispensable. shRNA silencing of AKT2 but not AKT1 promotes regression of prostate cancer xenografts. 24838891

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Furthermore, we showed in preclinical models that BRG1 antagonist selectively inhibited the progression of PTEN-deficient prostate tumors. 30496141

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation BEFREE One somatic mutation (17%), a 1 bp deletion, was detected in exon 7 of the gene, in one tumor, indicating that somatic mutations of the PTEN gene may occur in primary prostate tumors. 9671408

1998

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE Retroviral expression of constitutively active Notch-1 in human prostate tumor cell lines resulted in increased PTEN gene expression. 19479935

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. 17826033

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is lost as a function of prostate tumor androgen dependence. 16637073

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Met was amplified in 67% of prostate tumors from Pten p53 prostate conditional null mice and in approximately 30% of metastatic human prostate cancer specimens, often in association with loss of PTEN and TP53. 25381262

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE PTEN loss stimulates prostate tumor progression by sustaining AKT activation.Nowak et al.(2019.<i>J. 31145683

2019

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE Immunofluorescence data and western blot analyses determined that a lentivirus containing a 5'UTR derived from FGF-2 is the best candidate for directing selective gene expression in the prostate tumors of PTEN(-/-) mice in vivo. 21921943

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE In this study, we show that patients who develop prostate tumors with low levels of PTEN and high levels of HER2/3 have a poor prognosis. 21930937

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE IGF-IR expression positively correlates with PTEN and inversely correlates with NRP2 in prostate tumors. 22777769

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE Here, we provide evidence that PTEN loss in prostate tumours upregulates the expression of ADAM17, thereby activating NOTCH signalling. 27941799

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors. 16496415

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation BEFREE Alterations in the PIK3CA and PTEN genes were assessed in 40 prostate tumors (radical prostatectomy samples). 19443396

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 GeneticVariation BEFREE We studied the sensitivity and specificity of PTEN immunohistochemistry relative to four-color fluorescence in situ hybridization (FISH) for detection of PTEN gene deletion in a multi-institutional cohort of 731 primary prostate tumors. 27174589

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Here we show that at the onset of senescence, PTEN null prostate tumours in mice are massively infiltrated by a population of CD11b(+)Gr-1(+) myeloid cells that protect a fraction of proliferating tumour cells from senescence, thus sustaining tumour growth. 25156255

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE PTEN loss in Gleason score 6 biopsies identifies a subset of prostate tumors at increased risk of upgrading at radical prostatectomy. 24993522

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Based on the identification of mutations in sporadic breast, brain and prostate tumours, we decided to examine the potential role of PTEN in sporadic malignant melanoma. 9764804

1998

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 AlteredExpression BEFREE In the sc implanted human prostate tumors (22Rv-1) in nude mice, AN-7 significantly inhibited Ki-67, HIF-1alpha, HER-2/neu, bFGF and increased PTEN level. 17611019

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.600 Biomarker BEFREE Finally, higher levels of Akt activation are observed in human prostate cancer cell lines and xenografts lacking PTEN/MMAC1 expression when compared with PTEN/MMAC1-positive prostate tumors or normal prostate tissue. 9861013

1998