×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
MGD
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
The PTEN gene, located on 10q23, has recently been implicated as a candidate tumor suppressor gene in brain, breast and prostate tumors .
9331072 1997
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
9371490 1997
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
BEFREE
One somatic mutation (17%), a 1 bp deletion, was detected in exon 7 of the gene, in one tumor, indicating that somatic mutations of the PTEN gene may occur in primary prostate tumors .
9671408 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Based on the identification of mutations in sporadic breast, brain and prostate tumours , we decided to examine the potential role of PTEN in sporadic malignant melanoma.
9764804 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
BEFREE
To further define the role of PTEN/MMAC1 in the development of prostate cancer and its spectrum of genetic alterations, we analysed 40 pT2 or pT3 prostate tumors for allelic loss, mutations, and homozygous deletions using PCR-based methods.
9788441 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Finally, higher levels of Akt activation are observed in human prostate cancer cell lines and xenografts lacking PTEN/MMAC1 expression when compared with PTEN/MMAC1 -positive prostate tumors or normal prostate tissue.
9861013 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer.
12168088 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli.
12190124 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
12429629 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells.
15205473 2004
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
LHGDN
PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.
15492994 2004
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Metastatic properties of prostate cancer cells are controlled by VEGF.
15500293 2005
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis.
15897909 2005
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.
16421604 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.
16432235 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors .
16496415 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
BEFREE
Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors .
16496415 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is lost as a function of prostate tumor androgen dependence.16637073 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Expression of mTOR signaling pathway markers in prostate cancer progression.
16652388 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
16697957 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Integrative molecular concept modeling of prostate cancer progression.
17173048 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
The role of PTEN in prostate cancer cell tropism to the bone micro-environment.
17347137 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer.
17372210 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
PosttranslationalModification
LHGDN
Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation.
17606718 2007