×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
MGD
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is lost as a function of prostate tumor androgen dependence.16637073 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
PTEN loss in Gleason score 6 biopsies identifies a subset of prostate tumors at increased risk of upgrading at radical prostatectomy.24993522 2015
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
PTEN loss stimulates prostate tumor progression by sustaining AKT activation.Nowak et al.(2019.<i>J.31145683 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
28319090 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
19396168 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
BEFREE
Alterations in the PIK3CA and PTEN genes were assessed in 40 prostate tumors (radical prostatectomy samples).
19443396 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
29335545 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Based on the identification of mutations in sporadic breast, brain and prostate tumours , we decided to examine the potential role of PTEN in sporadic malignant melanoma.
9764804 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Behavioral stress inhibited apoptosis and delayed prostate tumor involution both in phosphatase and tensin homolog -deficient (PTEN -deficient) prostate cancer xenografts treated with PI3K inhibitor and in prostate tumors of mice with prostate-restricted expression of c-MYC (Hi-Myc mice) subjected to androgen ablation therapy with bicalutamide.
23348742 2013
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations.
29295717 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
PosttranslationalModification
LHGDN
Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation.
17606718 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
22581815 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.
23248098 2013
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli.
12190124 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
12429629 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
22610119 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Expression of mTOR signaling pathway markers in prostate cancer progression.
16652388 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis.
15897909 2005
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Finally, higher levels of Akt activation are observed in human prostate cancer cell lines and xenografts lacking PTEN/MMAC1 expression when compared with PTEN/MMAC1 -positive prostate tumors or normal prostate tissue.
9861013 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
9371490 1997
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN -deficient mice).
29051161 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Furthermore, we showed in preclinical models that BRG1 antagonist selectively inhibited the progression of PTEN -deficient prostate tumors .
30496141 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Here we show that at the onset of senescence, PTEN null prostate tumours in mice are massively infiltrated by a population of CD11b(+)Gr-1(+) myeloid cells that protect a fraction of proliferating tumour cells from senescence, thus sustaining tumour growth.
25156255 2014
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
BEFREE
Here, we provide evidence that PTEN loss in prostate tumours upregulates the expression of ADAM17, thereby activating NOTCH signalling.
27941799 2016