×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
PosttranslationalModification
LHGDN
Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation.
17606718 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
The role of PTEN in prostate cancer cell tropism to the bone micro-environment.
17347137 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
LHGDN
PTEN mutations do not cause nuclear beta-catenin accumulation in endometrial carcinomas.
15492994 2004
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
[Role of PTEN protein in multidrug resistance of prostate cancer cells].
18702307 2008
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Integrative molecular concept modeling of prostate cancer progression.
17173048 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
BEFREE
To further define the role of PTEN/MMAC1 in the development of prostate cancer and its spectrum of genetic alterations, we analysed 40 pT2 or pT3 prostate tumors for allelic loss, mutations, and homozygous deletions using PCR-based methods.
9788441 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer.
17372210 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
22581815 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Pten inactivation and the emergence of androgen-independent prostate cancer.
17638861 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo.
25007053 2014
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli.
12190124 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
We have quantitatively analyzed the mRNA levels of TMPRSS2-ERG, ERG, PTEN , and AR (n = 83), as well as ERG immunostaining (n = 78) in a series of prostate tumors .
25939480 2015
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
16697957 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
LHGDN
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.
16432235 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN -deficient mice).
29051161 2017
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
LHGDN
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
12429629 2002
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
The PTEN gene, located on 10q23, has recently been implicated as a candidate tumor suppressor gene in brain, breast and prostate tumors .
9331072 1997
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Here, we show that AKT2 is exclusively required for PTEN -deficient prostate tumor spheroid maintenance, whereas AKT1 is dispensable. shRNA silencing of AKT2 but not AKT1 promotes regression of prostate cancer xenografts.
24838891 2014
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.
16421604 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Furthermore, we showed in preclinical models that BRG1 antagonist selectively inhibited the progression of PTEN -deficient prostate tumors .
30496141 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
CTD_human
Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations.
29295717 2018
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
GeneticVariation
BEFREE
One somatic mutation (17%), a 1 bp deletion, was detected in exon 7 of the gene, in one tumor, indicating that somatic mutations of the PTEN gene may occur in primary prostate tumors .
9671408 1998
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
AlteredExpression
BEFREE
Retroviral expression of constitutively active Notch-1 in human prostate tumor cell lines resulted in increased PTEN gene expression.
19479935 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
PI3K/PTEN /AKT signaling regulates prostate tumor angiogenesis.
17826033 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Prostatic Neoplasms
0.600
Biomarker
BEFREE
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is lost as a function of prostate tumor androgen dependence.16637073 2006