Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Thus, the PGC-1alpha gene locus influences carbohydrate metabolism and contributes to type 2 diabetes in the population studied. 15111510

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to inhibit hepatic gluconeogenesis, could be potentially used for treatment of T2D. 28340340

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Together, these results showed that PPARG Pro12Ala and PPARGC1A Gly482Ser variants are associated, alone and in interaction, with insulin and glucose homeostasis and suggest that gene-gene interactions should be taken into account in candidate gene studies of T2DM to identify subjects with markedly different risks of developing the disease. 19536736

2009

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM. 12832613

2003

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. 16896940

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The results of this study suggested that the PGC-1 gene might be implicated in the pathogenesis of Type II diabetes. 12107756

2002

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We did not find any significant association between three SNPs in the PGC-1alpha gene and T2DM in Hispanics or NHW; however, using FBAT, we found the common Thr612Thr allele of the PGC-1alpha gene to be associated with T2DM among Hispanic subjects carrying the rare Pro12Ala allele of the PPAR-gamma gene (p=.003). 17479445

2007

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, we suggest that the AA genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of type 2 diabetes in Caucasians. 15581067

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes. 16474966

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Melatonin supplementation in combination with exercise behavior may ameliorate IR, hypertension and exercise performance or fatigue possibly by improving antioxidative activities, hyperlipidemia, inflammatory cytokines via up-regulation of GLUT4, PGC-1 α and mitochondrial biogenesis in T2DM rats. 28578257

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension. 18614852

2008

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM. 25928419

2015

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated. 11793024

2001

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We conclude that the Pro12Pro genotype of the PPAR-gamma2 gene and the 482Ser allele of the PGC-1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. 15592662

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The objective of this case-control study was to explore the relationship between SNPs of PGC-1alpha and type 2 diabetes in the southern Chinese population and to determine whether the common variants: Gly482Ser and Thr394Thr, in the PGC-1alpha gene have any impacts on interaction with myocyte enhancer factor (MEF) 2C. 18067759

2007

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. 17310221

2007

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Moreover, the anti-diabetic effect of PPD and PPT appeared to be partially mediated by the suppression of hepatic metabolism genes expression such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase, as well as facilitating lipid metabolism genes expression such as microsomal TG transfer protein in the liver tissues of T2DM mice. 28824430

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Histological results confirmed that renal expression of key proteins was reduced in DKD patients with respect to mitochondrial biogenesis (PGC-1α, p-AMPK) and FA oxidation (PPAR-α, CPT-1) as compared to that in the control and T2DM groups. 28956034

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We conducted a meta-analysis to assess the association between three polymorphisms (Gly482Ser, Thr394Thr and Thr612Met) in PPARGC1A and T2DM. 21294239

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The present study provides evidence that a common haplotype of PPARGC1A genetic polymorphisms are moderately associated with T2D in Han Chinese population. 19828207

2009

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE This study aimed to investigate DNA promoter methylation and gene expression of PPARGC1A in skeletal muscle from first degree relatives (FDR) of T2D patients, and to determine the association with insulin action as well as the influence of family relation. 23505498

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men. 23210442

2012

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE We can conclude that reduced PGC-1alpha expression described in Type 2 diabetes may be partly explained by muscle inactivity. 16326070

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE These data suggest that the PGC-1α Thr394Thr and Gly482Ser polymorphisms are associated with therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with type 2 diabetes mellitus. 20498286

2010

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE PPARGC1A mRNA expression was reduced by 90% (p<0.005) and correlated with the reduction in insulin secretion in islets from patients with type 2 diabetes. 18270681

2008