Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated. 11793024

2001

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The results of this study suggested that the PGC-1 gene might be implicated in the pathogenesis of Type II diabetes. 12107756

2002

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM. 12832613

2003

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population. 12606537

2003

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Thus, the PGC-1alpha gene locus influences carbohydrate metabolism and contributes to type 2 diabetes in the population studied. 15111510

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, we suggest that the AA genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of type 2 diabetes in Caucasians. 15581067

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE We conclude that the Pro12Pro genotype of the PPAR-gamma2 gene and the 482Ser allele of the PGC-1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. 15592662

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here. 15824463

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes. 15599700

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE PGC-1alpha and PGC-1beta mRNA levels and the mitochondrial genes they regulate are decreased in muscle of people with prediabetes and T2DM. 15545992

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The prevalent Gly482Ser variant in PGC-1 was shown to be associated with type 2 diabetes in some but not all studies. 15146371

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE The nuclear hormone receptor coactivator PGC-1 (peroxisome proliferator-activated (PPAR)-gamma coactivator-1) has been implicated in the onset of type 2 diabetes. 15107844

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy. 15782399

2005

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE There was no strong association between SNPs or haplotypes of PPARGC1A and type 2 diabetes. 15937669

2005

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE We conclude that PPARGC1A is likely to contribute to the risk of diabetes in offspring of patients with type 2 diabetes. 15912394

2005

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The A allele of Thr394Thr (G --> A) polymorphism of the PGC-1 gene is associated with Type 2 diabetes in Asian Indian subjects and the XA genotype confers 1.6 times higher risk for Type 2 diabetes compared with the GG genotype in this population. 16241916

2005

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Recent studies suggested linkage between the chromosomal region of PGC-1alpha and fasting serum insulin levels, and associates a Gly482Ser polymorphism of the gene with type 2 diabetes and hypertension. 15649578

2005

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives. 16896940

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes. 16474966

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE We can conclude that reduced PGC-1alpha expression described in Type 2 diabetes may be partly explained by muscle inactivity. 16326070

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE This review focuses on the role of PGC-1alpha in glucose metabolism and considers how PGC-1alpha links cellular glucose metabolism, insulin sensitivity and mitochondrial function, and why defects in PGC-1alpha expression and regulation may contribute to the pathophysiology of type 2 diabetes in humans. 16752166

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE This study aimed to investigate whether genetic variations in human PPARGC1 gene are associated with metabolic syndrome-related phenotypes and T2D among obese subjects. 16122961

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE PGC-1alpha gene and physical activity in type 2 diabetes mellitus. 17031255

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE The observation that PPARGC1A and the PPARs were upregulated in the adipose tissue of type 2 diabetic patients, along with the finding that adipose tissue from some patients with type 2 diabetes can express UCP1 mRNA, suggests that in these patients white adipose tissue may move towards a brown adipose tissue phenotype. 16538490

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Several studies have suggested that the common PPARGC1A polymorphism Gly482Ser may be associated with risk of type 2 diabetes, with conflicting results. 16435105

2006