PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
PGC-1alpha and PGC-1beta mRNA levels and the mitochondrial genes they regulate are decreased in muscle of people with prediabetes and T2DM.
|
15545992 |
2004 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
PGC-1alpha gene and physical activity in type 2 diabetes mellitus.
|
17031255 |
2006 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
PPARGC1A mRNA expression was reduced by 90% (p<0.005) and correlated with the reduction in insulin secretion in islets from patients with type 2 diabetes.
|
18270681 |
2008 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
PGC-1α plays a central role in hepatic gluconeogenesis and has been implicated in the onset of type 2 diabetes.
|
25497092 |
2014 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
A haplotype-based gene-gene interaction was observed significantly (U = -6.28, P < .001), indicating the possibility of an interaction between haplotype AAG of the PPARGC1A gene and haplotypes CTCG (odds ratio [OR] = 1.745, 95% confidence interval [95% CI] 1.069-2.847) and CTCA (OR = 0.239, 95% CI 0.060-0.958) of the UCP1 gene.Haplotype-based interaction between the PPARGC1A and UCP1 genes is associated with IFG or T2DM among residents in Henan, China.
|
28591028 |
2017 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population.
|
12606537 |
2003 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes.
|
20175989 |
2011 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
An interaction between ERRα and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) has also recently been shown to regulate an enzyme in the β-oxidation of free fatty acids, thereby suggesting that ERRα plays an important role in obesity and type 2 diabetes.
|
29216352 |
2018 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Associations of PGC-1α variants rs10517030 and rs10212638 with T2DM were analyzed in a dominant genetic model, and were tested for interactions of genotypes and nutrients with T2DM risk.
|
28488691 |
2017 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men.
|
23210442 |
2012 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Collectively, we propose FGFR1 in adipose tissues as a major functional receptor for FGF21, as an upstream regulator of PGC-1α, and as a compelling target for antibody-based therapy for type 2 diabetes and other obesity-associated disorders.
|
22174314 |
2011 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM.
|
12832613 |
2003 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated.
|
11793024 |
2001 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Furthermore, our research pinpoints the role of several new T2D-associated genes (such as Srebf1 and Ppargc1) in the human population.
|
25758573 |
2014 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension.
|
18614852 |
2008 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.
|
24359475 |
2014 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D.
|
20410232 |
2010 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM.
|
28418876 |
2017 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes.
|
15599700 |
2004 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
HG-HF significantly depressed expression of PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α) and OPA1 (optic atrophy 1) by reducing [Ca<sup>2+</sup>]<sub>i</sub>, whereas OPA1 supplementation partly reversed those detrimental effects induced by TRPV1<sup>-/-</sup> Furthermore, capsaicin treatment not only attenuated CMECs injury induced by HG-HF but also mitigated cardiac microvascular injury induced by T2DM.
|
29735636 |
2018 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Histological results confirmed that renal expression of key proteins was reduced in DKD patients with respect to mitochondrial biogenesis (PGC-1α, p-AMPK) and FA oxidation (PPAR-α, CPT-1) as compared to that in the control and T2DM groups.
|
28956034 |
2017 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus.
|
17310221 |
2007 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM.
|
25928419 |
2015 |
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.
|
15824463 |
2004 |