Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE PGC-1alpha and PGC-1beta mRNA levels and the mitochondrial genes they regulate are decreased in muscle of people with prediabetes and T2DM. 15545992

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE PGC-1alpha gene and physical activity in type 2 diabetes mellitus. 17031255

2006

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE PPARGC1A mRNA expression was reduced by 90% (p<0.005) and correlated with the reduction in insulin secretion in islets from patients with type 2 diabetes. 18270681

2008

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE PGC-1α plays a central role in hepatic gluconeogenesis and has been implicated in the onset of type 2 diabetes. 25497092

2014

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE A haplotype-based gene-gene interaction was observed significantly (U = -6.28, P < .001), indicating the possibility of an interaction between haplotype AAG of the PPARGC1A gene and haplotypes CTCG (odds ratio [OR] = 1.745, 95% confidence interval [95% CI] 1.069-2.847) and CTCA (OR = 0.239, 95% CI 0.060-0.958) of the UCP1 gene.Haplotype-based interaction between the PPARGC1A and UCP1 genes is associated with IFG or T2DM among residents in Henan, China. 28591028

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE A single nucleotide polymorphism within the coding region of the PGC-1 gene predicts a glycine to serine substitution at amino acid 482 and has been associated with type 2 diabetes in a Danish population. 12606537

2003

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function. 29186342

2018

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes. 20175989

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE An interaction between ERRα and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) has also recently been shown to regulate an enzyme in the β-oxidation of free fatty acids, thereby suggesting that ERRα plays an important role in obesity and type 2 diabetes. 29216352

2018

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Associations of PGC-1α variants rs10517030 and rs10212638 with T2DM were analyzed in a dominant genetic model, and were tested for interactions of genotypes and nutrients with T2DM risk. 28488691

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men. 23210442

2012

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Collectively, we propose FGFR1 in adipose tissues as a major functional receptor for FGF21, as an upstream regulator of PGC-1α, and as a compelling target for antibody-based therapy for type 2 diabetes and other obesity-associated disorders. 22174314

2011

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM. 12832613

2003

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated. 11793024

2001

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Furthermore, our research pinpoints the role of several new T2D-associated genes (such as Srebf1 and Ppargc1) in the human population. 25758573

2014

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension. 18614852

2008

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes. 24359475

2014

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D. 20410232

2010

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM. 28418876

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes. 15599700

2004

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE HG-HF significantly depressed expression of PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α) and OPA1 (optic atrophy 1) by reducing [Ca<sup>2+</sup>]<sub>i</sub>, whereas OPA1 supplementation partly reversed those detrimental effects induced by TRPV1<sup>-/-</sup> Furthermore, capsaicin treatment not only attenuated CMECs injury induced by HG-HF but also mitigated cardiac microvascular injury induced by T2DM. 29735636

2018

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker BEFREE Histological results confirmed that renal expression of key proteins was reduced in DKD patients with respect to mitochondrial biogenesis (PGC-1α, p-AMPK) and FA oxidation (PPAR-α, CPT-1) as compared to that in the control and T2DM groups. 28956034

2017

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression BEFREE Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. 17310221

2007

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM. 25928419

2015

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation BEFREE In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here. 15824463

2004