Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE "BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. 18955455

2009

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE 691 female BRCA1/2 mutation carriers without breast or ovarian cancer at time of family ascertainment were identified; 346 BRCA1 and 345 BRCA2. 24249359

2014

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Ovarian cancer penetrance for BRCA1 and BRCA2 combined was 22% (6-65%) by age 80. 11044354

2000

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Ovarian cancer survival in Ashkenazi Jewish patients with BRCA1 and BRCA2 mutations. 11373105

2001

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. 22253144

2012

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2-mutated families presented breast and ovarian cancers or breast cancers only, whereas most BRCA1-mutated families presented ovarian cancer alone or in association with breast cancer. 10449599

1999

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 mutations were less common than BRCA1 mutations in families with any history of ovarian carcinoma. 10717622

2000

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 mutation analysis of 87 Spanish breast/ovarian cancer families. 11843247

2002

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer? 12504001

2003

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 mutations predispose carriers to breast and ovarian cancer and can also cause other cancers and Fanconi anemia. 16793542

2006

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Breast Cancer 2 gene (BRCA2) mutation carriers have a 45% chance of developing breast cancer and a 11% risk of developing ovarian cancer by the age of 70. 21671020

2012

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 mutations have been linked to melanoma in large breast and ovarian cancer families, though a statistically significant elevated risk was reported in only one study. 25524463

2016

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. 26586665

2016

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Breast cancer 2 (BRCA2)-associated breast and ovarian cancers are sensitive to platinum-based chemotherapy. 28608931

2017

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 mutations in primary breast and ovarian cancers. 8640235

1996

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE BRCA2 carries a risk of breast cancer similar to that of BRCA1, but is associated with a lower risk of ovarian cancer and a higher risk of male breast cancer. 8791478

1997

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A BRCA2 mutation was found in eight of 34 women with ovarian cancer and a family history of stomach cancer versus three of 75 women with ovarian cancer and a family history of ovarian cancer, but not of stomach cancer (odds ratio=7.4; 95% CI 1.8-30; P=0.004). 14647210

2004

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A consecutive sample of 205 women with primary ovarian cancer was screened for mutations in the BRCA1 and BRCA2 genes using a direct test for small deletions and insertions, conformational sensitive gel electrophoresis and direct sequencing. 15617999

2005

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE A Cost-Effectiveness Evaluation of Germline BRCA1 and BRCA2 Testing in UK Women with Ovarian Cancer. 28407998

2017

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A genome-wide search for such alterations was performed by comparative genomic hybridization analysis on BRCA1 and BRCA2 mutation-positive (n = 20) ovarian carcinoma specimens. 9661879

1998

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients. 20215541

2010

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family. 9537232

1998

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A large fraction of sequence variants of unknown significance (VUS) of the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 may induce splicing defects. 21673748

2012

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. 26698676

2016

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A missense mutation in the BRCA2 gene in three siblings with ovarian cancer. 9579822

1998