Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.360 Biomarker BEFREE Here we report that the FR-alpha gene promoter is repressed in the presence of 17beta-estradiol and derepressed by the antiestrogens tamoxifen and ICI 182780 in a promoter-specific and ER-alpha-dependent manner in carcinoma cell lines including HeLa (cervical carcinoma), BG-1 (ovarian carcinoma), and IGROV-1 (ovarian carcinoma). 12782587

2003

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.360 AlteredExpression BEFREE Our results indicate that the determination of ESR1 levels by kinetic PCR may be superior to immunohistochemical methods in assessment of biologically relevant levels of ER expression in ovarian carcinoma, and is feasible in routinely used FFPE tissue. 19675076

2009

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.360 AlteredExpression BEFREE Assessment of estrogen receptor (ER) expression by immunohistochemistry has yielded inconsistent results as a prognostic indicator in ovarian carcinoma. 21102415

2011

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.360 AlteredExpression BEFREE Exploiting MEK inhibitor-mediated activation of ERα for therapeutic intervention in ER-positive ovarian carcinoma. 23390495

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.360 PosttranslationalModification BEFREE Previous studies have shown that ESR1 methylation influences ovarian cancer development and might thus play a role regarding prognosis of ovarian carcinoma. 24908329

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.360 Biomarker BEFREE Here we assess the expression levels of progesterone receptor (PR), estrogen receptor alpha (ER) and androgen receptor (AR) using histoscore - a nuclear scoring method incorporating both proportion of positive cells and the intensity of nuclear staining - across a cohort of 107 WT1 negative EnOCs. 31495455

2019