Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker PSYGENET The mRNA expressions of the genes encoding for COX-2, MPO, iNOS and sPLA2-IIA were significantly increased in the peripheral blood cells of depressed patients versus controls. 22331023

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker PSYGENET Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070

2010

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker CTD_human These results suggest that COX-2 enzyme might play a key role in pathophysiology of depression. 19356723

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker PSYGENET There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker CTD_human Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression. 19356723

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker PSYGENET Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.560 Biomarker PSYGENET Patients with chronic hepatitis C viral infection (n = 132) were assessed to examine the effects of seven single nucleotide polymorphisms in COX2 and PLA2 genes on the development of depression during interferon (IFN)-alpha treatment; a subsample (n = 63) was assessed for the erythrocyte levels of the three main polyunsaturated fatty acids, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid. 20034614

2010