Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Cooperative expression of the amplified c-myc and c-erbB-1 genes might be involved in the genesis or progression of the gastric cancer. 3102422

1986

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE DNA ploidy, proliferative index, and epidermal growth factor receptor: expression and prognosis in patients with gastric cancers. 7723282

1995

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Amplification of epidermal growth factor receptor gene and its relationship to survival in human gastric cancer. 7715901

1995

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE These results suggest that an adenoviral vector system targeting the down-regulation of EGFR could be a good candidate for the therapy of gastric cancers that overexpress EGFR. 10505852

1999

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE We examined the expression of NRP-1 mRNA and EGF-R protein in seven human gastric cancer cell lines. 12618892

2003

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells, both of which have been proposed as prognostic markers of gastric cancers. 15556605

2004

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE These biological factors are often derived from the genetic process, which is thought to represent a crucial step to gastric cancer (DNA copy number changes, microsatellite instability, thymidilate synthase, E-cadherin, beta-catenin, mucin antigen, p53, c-erb B-2, COX-2, matrix metalloproteinases, VEGFR and EGFR). 15245777

2004

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Epidermal growth factor receptor and c-erbB-2 contents in unresectable (UICC R1 or R2) gastric cancer. 14535591

2004

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Because of the causal involvement of EGFR and its ligands in gastric cancer growth, we investigated expression of ERRP and cell proliferation in human gastric cancer. 15647181

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Epidermal growth factor receptor (EGFR): mutational and protein expression analysis in gastric cancer. 17094480

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In the current study we explored the role of EGFR and its potential use as a therapeutic target in gastric cancer. 16865277

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer. 18231104

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Our data warrant further investigations on the strategy of co-targeting IGF-1R and EGFR in GC. 18544998

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE These results reveal that both the FGFR2 and EGFR family signaling pathways are activated in FGFR2-amplified gastric cancer cell lines to drive cell proliferation and survival. 18381441

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE We considered that searching for EGFR alterations in gastric cancer is likely to be clinically important in order to identify patients susceptible to respond to tyrosine kinase inhibitors. 18199332

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE In conclusion, these preliminary data confirm the importance of EGFR and VEGFR signaling in gastric cancer and suggest that the simultaneous inhibition of RTK-pathways through sunitinib and vandetanib may provide therapeutic benefit in this disease. 20039326

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE This study was performed to clarify the effect of epidermal growth factor receptor (EGFR) inhibitors in combination with SN38, an active metabolite of irinotecan, on the proliferation of irinotecan-refractory gastric cancer. 21997136

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE We investigated the clinical significance of miR-146a in gastric cancer, in particular focusing on hypothetical miR-146a target genes, such as epidermal growth factor receptor (EGFR) and interleukin-1 receptor-associated kinase (IRAK1). 21632853

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Epidermal growth factor receptor mutation in gastric cancer. 21436633

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. 21482691

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated in clinical studies. 22614881

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Cetuximab is effective in K-ras wild-type, EGFR-expressing gastric cancer cell lines and xenografts. 22011788

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated. 22290393

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The epidermal growth factor receptor (EGFR) is a potential target of anticancer therapy in gastric cancer. 23153332

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Combination treatment regimens with EGFR-targeting agents and cytotoxic agents are considered to be a potential therapeutic option for EGFR-overexpressing GC. 22139134

2012