Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. 11222871

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. 12655533

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. 12006526

2002

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Evaluation of the HER2/neu-derived peptide GP2 for use in a peptide-based breast cancer vaccine trial. 16596621

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level. 19896266

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Selective death of human breast cancer cells by lytic immunoliposomes: Correlation with their HER2 expression level. 19896266

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. 16682728

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human HER-2/neu is expressed in human renal cell carcinoma at heterogeneous levels independently of tumor grading and staging and can be recognized by HLA-A2.1-restricted cytotoxic T lymphocytes. 10897039

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. 20197467

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. 25221644

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. 12006526

2002

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. 25221644

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. 20197467

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Combining the anti-HER2 antibody trastuzumab with taxanes in breast cancer: results and trial considerations. 11970740

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. 12655533

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Prognostic Significance of VEGFC and VEGFR1 mRNA Expression According to HER2 Status in Breast Cancer: A Study of Primary Tumors from Patients with High-risk Early Breast Cancer Participating in a Randomized Hellenic Cooperative Oncology Group Trial. 26124351

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. 16495393

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Evaluation of the HER2/neu-derived peptide GP2 for use in a peptide-based breast cancer vaccine trial. 16596621

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Molecular profiling of single circulating tumor cells with diagnostic intention. 25358515

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer. 21638049

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human HER2 overexpression as a predictive marker in a randomized trial comparing adjuvant cyclophosphamide/methotrexate/5-fluorouracil with epirubicin in patients with stage I/II breast cancer: long-term results. 16137437

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. 11222871

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Biomarker CTD_human Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. 22302033

2012

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. 16091755

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human
0.300 Therapeutic CTD_human HER-2/neu is expressed in human renal cell carcinoma at heterogeneous levels independently of tumor grading and staging and can be recognized by HLA-A2.1-restricted cytotoxic T lymphocytes. 10897039

2000