Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Our findings indicate that the adverse prognosis associated with TP53 and PIK3CA mutations in human cancers can be functionally replicated in mouse models of type I→type II OvCA progression. 23499052

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE We used six whole-exome-sequenced primary HGSOC/USC cell-lines and three xenografts overexpressing HER2/neu and harboring mutated or wild-type PIK3CA/PIK3R1 genes to evaluate the role of PI3K-mutations as potential mechanism of resistance to afatinib, an FDA-approved pan-c-erb-inhibitor in clinical trials in USC. 30630630

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Recently, it has been reported that somatic mutations within the PI3K catalytic subunit, PIK3CA, are common (25-40%) among colorectal, gastric, breast, ovarian cancers, and high-grade brain tumors. 16288007

2005

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE One patient exhibited mutations both in PIK3CA and PTEN at discordant sites between endometrial and ovarian carcinomas, whereas the other 4 exhibited concordant mutations. 22635024

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation UNIPROT Our study is the first direct evidence that PIK3CA is an oncogene in ovarian cancer and greatly extends recent findings in breast cancer. 15520168

2004

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE We also found that an activating (E545K) Pik3ca mutation, unlike Pten inactivation or Pik3ca H1047R mutation, cannot cooperate with Arid1a loss to promote ovarian cancer development in the mouse. 26279473

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas. 24036443

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE PIK3CA mutations in advanced ovarian carcinomas. 15712344

2005

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE The PIK3CA amplification (predominantly a low-level) was found in 28/117 (24%) ovarian carcinomas. 19029838

2009

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Interaction between PIK3CA rs3976507 and rs6443626 loci, and factors such as BMI, number of liveborn, tobacco, alcohol, and family history of ovarian cancer are associated with ovarian cancer risk. 31288947

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Although many tumors presented a single lesion (28/93, of which 23 overexpressed PIK3CA, 1 overexpressed AKT and 4 had lost PTEN), many OC (35/93) presented multiple alterations within the PI3K pathway. 23408974

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Sequence mutations and gene amplifications lead to activation of the PIK3CA-AKT2 signaling pathway and have been reported in several types of neoplasms including ovarian cancer. 16721043

2006

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 GeneticVariation BEFREE Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer. 27681437

2016

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Likewise, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is also a central regulator of the ovarian cancer. 29401696

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Our study is the first direct evidence that PIK3CA is an oncogene in ovarian cancer and greatly extends recent findings in breast cancer. 15520168

2004

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. 25677064

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Our results indicate that FAK inhibition can suppress ovarian cancer cells migration and invasion through inhibiting downstream signaling (PI3K/AKT), which might be a therapeutic target or biomarker for ovarian cancer. 24115647

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE The current results highlight the role of miR‑381‑mediated regulation of PIK3CA in the development and progression of ovarian cancer and suggest that restoration of miR‑381 to normal levels in ovarian cancer cells may constitute a therapeutic strategy for patients. 30542723

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance. 29930760

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE High prevalence of genetic alterations in PI3K/AKT pathway in a Middle Eastern ovarian carcinoma provides genetic evidence supporting the notion that dysregulated PI3K/AKT pathways play an important role in the pathogenesis of ovarian cancers. 19638206

2009

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Here, we show that dual inhibition of PI3K/mTOR in ovarian cancer-spheroids leads to death of inner matrix-deprived cells, whereas matrix-attached cells are resistant. 22340595

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Our observations suggest PIK3CA is an oncogene that has an important role in ovarian cancer. 9916799

1999

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Overexpression of SOX2 is involved in paclitaxel resistance of ovarian cancer via the PI3K/Akt pathway. 26159849

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Activation of the phosphatidylinositol 3' kinase (PI3K) pathway occurs in a significant fraction of both types of ovarian cancer, driven predominantly by mutations in type I and amplification in type II. 22585163

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.700 Biomarker BEFREE Targeting EGFR and PI3K pathways in ovarian cancer. 24022196

2013