Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347

2003

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203

2008

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. 21843009

2011

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker PSYGENET Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. 25583186

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker PSYGENET The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. 25510949

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker PSYGENET Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. 24972302

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human The smaller effects of the 5-HTT polymorphism on depression may be explained by an interaction between the genes (F = 5.0, d.f. 18458677

2009

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker PSYGENET Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression. 23588187

2014

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker PSYGENET GABAergic functions, expressed in extracellular paired-pulse depression, and in IPSCs recorded in dentate granular cells were enhanced in Tg-SOD-1 mice. 10594078

1999

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker PSYGENET We conclude that a constitutive partial reduction in NCAM proteins results in a behavioural phenotype related to depression without impairment in cognitive functions, also affecting the level of FGFR1 phosphorylation without major alterations in CaMKII and CaMKIV intracellular signalling. 22361116

2012

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker PSYGENET The changes in mitochondrial activity in brain and reduced expressions of superoxide dismutase (SOD1, SOD2), mitofusin (Mfn1, Mfn2) as well as brain-derived neurotrophic factor (BDNF) suggest that both CORT and CUMS may impair mitochondrial function and/or expressions of mitofusion and antioxidant enzymes that, in turn, may increase oxidative stress and reduce energy production in brain with depression-like behaviors. 22244747

2012

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker PSYGENET Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer. 19204725

2009

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker PSYGENET Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. 14695195

2003

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker CTD_human Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment. 19605942

2009

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker PSYGENET Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects. 23261523

2013

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker CTD_human FGFR1 mRNA expression was higher in depression than in the other groups in CA1, CA4 and DG. 16861106

2006

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Furthermore, the TPH2(-/-) mouse may serve as a useful model in the search for new medications that have therapeutic targets for depression that are outside of the 5HT neuronal system. 25089765

2014

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET The results of our analysis indicated no significant differences in the frequencies of the single alleles and genotypes of two polymorphisms in TPH2 gene between LOD patients and normal controls. 26057341

2015

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test. 25578258

2015

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming. 24630468

2014

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET Common polymorphisms involved in the tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), serotonin transporter, monoamine oxidase A (MAOA) and brain-derived neurotrophic factor (BDNF) were investigated in a naturalistic inpatient study of the German research network on depression. 23063133

2013

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET TREK1 knockout mice have impaired PUFA-mediated neuroprotection to ischemia, reduced sensitivity to volatile anesthetics, altered perception of pain, and a depression-resistant phenotype. 21262820

2011

Entrez Id: 6281
Gene Symbol: S100A10
S100A10
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker PSYGENET P11 expression and PET in bipolar disorders. 21722919

2011

Entrez Id: 6281
Gene Symbol: S100A10
S100A10
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment. 21682946

2012