Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347

2003

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203

2008

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. 21843009

2011

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.700 Biomarker CTD_human The smaller effects of the 5-HTT polymorphism on depression may be explained by an interaction between the genes (F = 5.0, d.f. 18458677

2009

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker CTD_human Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment. 19605942

2009

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.620 Biomarker CTD_human FGFR1 mRNA expression was higher in depression than in the other groups in CA1, CA4 and DG. 16861106

2006

Entrez Id: 6281
Gene Symbol: S100A10
S100A10
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment. 21682946

2012

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. 16330021

2006

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. 21945287

2012

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Therapeutic CTD_human Overall, the results appear to sustain the importance of the FSL rats as an animal model of depression in view of the impairment of NPY genes and the ability of fluoxetine treatment to normalize NPY-related gene expression selectively in this strain. 9729278

1998

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human The data support our hypothesis that the NPY system dysregulation constitutes one of the biological underpinnings of depression and that one common mechanism of action of antidepressive treatment modalities may be effects on NPY and its receptors. 17572454

2007

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. 29643356

2018

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Overall, the results appear to sustain the importance of the FSL rats as an animal model of depression in view of the impairment of NPY genes and the ability of fluoxetine treatment to normalize NPY-related gene expression selectively in this strain. 9729278

1998

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human The results of the present study suggest that TPH2 gene expression in the midbrain part of the DRN is implicated in depression and stress response, as well as in the antidepressant fluoxetine action. 17950541

2007

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Similar to mice treated with selective serotonin reuptake inhibitors (SSRIs), TREK1 knockout mice are resistant to depression-like behavior and have elevated serotonin levels leading to speculation that TREK1 inhibition may contribute to the therapeutic effects of SSRIs. 21871532

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Patients suffering from depression have abnormal activity in stress responsive brain regions and elevated cerebrospinal fluid CRF. 12438692

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression. 19356723

2009

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Therapeutic CTD_human Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. 16330021

2006

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Therapeutic CTD_human Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. 21945287

2012

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human The association between the IL-6 polymorphism and reduced risk of depressive symptoms confirms the role of the inflammatory response system in the pathophysiology of IFN-alpha-induced depression; in contrast, the effect of the 5-HTT gene was small and perhaps dependent on the status of the inflammatory response. 18458677

2009

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. 17074966

2007

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Therapeutic CTD_human The data support our hypothesis that the NPY system dysregulation constitutes one of the biological underpinnings of depression and that one common mechanism of action of antidepressive treatment modalities may be effects on NPY and its receptors. 17572454

2007

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker CTD_human Increased synthesis of CRF in CeA amplified CRF and arginine vasopressin peptide concentration in the paraventricular nucleus of the hypothalamus, and decreased glucocorticoid negative feedback, both markers associated with the pathophysiology of depression. 18698320

2009

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.590 Biomarker CTD_human Depression scores at SCL-90 in addicted patients positively correlated with plasma ACTH and cortisol values. 18201294

2008