Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker CTD_human Hashimoto's thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice. 30373627

2018

Entrez Id: 2911
Gene Symbol: GRM1
GRM1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving. 24270186

2014

Entrez Id: 6403
Gene Symbol: SELP
SELP
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker CTD_human Platelet hyperactivity, neurobehavioral symptoms and depression among Indian women chronically exposed to low level of arsenic. 25451969

2014

Entrez Id: 5309
Gene Symbol: PITX3
PITX3
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Based on these results, we propose that Pitx3-/- mice may serve as a useful genetic animal model for co-morbid depressive disorder and parkinsonism. 24480473

2014

Entrez Id: 10014
Gene Symbol: HDAC5
HDAC5
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952

2014

Entrez Id: 5179
Gene Symbol: PENK
PENK
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Surprisingly, in PENK KO mice, we did not detect anxiety and depression-related behavioral changes after the CMS procedure, and even measured a decreased hormonal stress response. 24804898

2014

Entrez Id: 54738
Gene Symbol: FEV
FEV
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET We phenotyped Pet-1 KO mice for fear conditioning and extinction, and on a battery of assays for anxiety- and depression-related behaviors. 24100022

2013

Entrez Id: 2894
Gene Symbol: GRID1
GRID1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning. 23560106

2013

Entrez Id: 79053
Gene Symbol: ALG8
ALG8
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Among the cognate genes, six including ALG8, DGKE, GNA12, KLF11, LRPAP1, and MMAB are related to multiple genetic diseases such as depressive disorder and Type-II diabetes. 22348086

2012

Entrez Id: 2911
Gene Symbol: GRM1
GRM1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Growing evidence suggests an important role of the metabotropic glutamate receptor 1 (mGlu1) in depression-related phenotypes. 21962378

2012

Entrez Id: 2894
Gene Symbol: GRID1
GRID1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. 22412961

2012

Entrez Id: 3061
Gene Symbol: HCRTR1
HCRTR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes. 22617356

2012

Entrez Id: 23705
Gene Symbol: CADM1
CADM1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker CTD_human Furthermore, a candidate genetic locus that associates with baseline depressive-like behavior contains a gene that encodes for cellular proliferation/adhesion molecule (Cadm1), supporting a genetic basis for the role of neuro/gliogenesis in depression. 22113448

2012

Entrez Id: 2782
Gene Symbol: GNB1
GNB1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker CTD_human Glyoxylase 1 (GLO1) and guanine nucleotide-binding protein 1 (GNB1) mostly account for baseline anxiety-like and depressive-like behavior, indicating a common biological link between depression and anxiety. 22113448

2012

Entrez Id: 2911
Gene Symbol: GRM1
GRM1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Variations in postnatal maternal care and the epigenetic regulation of metabotropic glutamate receptor 1 expression and hippocampal function in the rat. 23045678

2012

Entrez Id: 4862
Gene Symbol: NPAS2
NPAS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 2894
Gene Symbol: GRID1
GRID1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. 22064162

2012

Entrez Id: 5584
Gene Symbol: PRKCI
PRKCI
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory. 22485133

2012

Entrez Id: 114784
Gene Symbol: CSMD2
CSMD2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. 22064162

2012

Entrez Id: 3061
Gene Symbol: HCRTR1
HCRTR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. 21377495

2011

Entrez Id: 2925
Gene Symbol: GRPR
GRPR
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET GRPR-KO mice were found to present with increased depression-like behavior. 21254899

2011

Entrez Id: 125958
Gene Symbol: OR7D4
OR7D4
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4. 21093532

2011

Entrez Id: 1607
Gene Symbol: DGKB
DGKB
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. 20976192

2010

Entrez Id: 4862
Gene Symbol: NPAS2
NPAS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker PSYGENET Polymorphisms in the circadian genes NPAS2, ARNTL, and RORA were also suggested to contribute to depression vulnerability. 19693801

2010

Entrez Id: 2931
Gene Symbol: GSK3A
GSK3A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker CTD_human Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. 20357757

2010