Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Additional regulators of apoptosis, such as the p53 tumor suppressor gene, may be altered in human cancers as one step in tumorigenesis. 1286168

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The data indicate an increased incidence of p53 abnormalities in the late stages of gastric carcinogenesis. 1302567

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Mutations of the p53 gene and other genes involving in human colorectal carcinogenesis. 1306299

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE These results indicate that inactivation of the p53 gene through mutations and the allelic deletion may play an important role in gastric tumorigenesis. 1322785

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Participation of p53 in this pathway suggests a mechanism for the contribution of abnormalities in p53 to tumorigenesis and genetic instability and provides a useful model for studies of the molecular mechanisms of p53 involvement in controlling the cell cycle. 1323840

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE A previous report using cervical carcinoma cell lines suggests that the inactivation of two tumor suppressor gene products, p53 and pRB, either by complex formation with the E6 and E7 proteins of oncogenic human papillomaviruses (HPVs) or by mutation, may be an important step in cervical carcinogenesis (M. Scheffner et al., Proc.Natl.Acad.Sci.USA, 88: 5523-5527, 1991). 1327506

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The discovery of the tumor suppressor genes, for which loss of function mutations are oncogenic as in the RB gene of the retinoblastoma and p53 gene, has introduced a new concept of oncogenesis which could be useful even in the cure of the neoplasms. 1331337

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE We suggest that the p53 mutations may be associated with smoking-induced lung carcinogenesis. 1348931

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE These findings are consistent with a recessive mechanism of action of p53 in WHO grade II and III astrocytoma tumorigenesis. 1349850

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Two recent studies have examined the role of p53 in immortalization and tumorigenesis. 1365909

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE These observations further support the notion that germline p53 mutation plays a key role in the tumorigenesis of individuals with Li-Fraumeni syndrome. 1373881

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis. 1394234

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The timing of p53 protein accumulation is favorable for an intermediate biomarker in multistage esophageal carcinogenesis. 1394236

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE The p53 tumour-suppressor gene is implicated in ovarian carcinogenesis, and our findings suggest that an important tumour-suppressor gene may be located in the region 17q23-qter. 1408149

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE As no mutations were detected in exons 5-8 in either tumor examined, the second p53 allele was most likely lost during tumorigenesis in both tumors. 1467311

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Our findings further implicate Rb and p53 derangements in mammary oncogenesis. 1468776

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE We conclude that p53 overexpression is one of the most common abnormalities identified in head and neck cancer, and may be a useful marker in the study of multistep progression of tumorigenesis. 1468914

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma. 1483923

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE The p53 tumor suppressor gene is of particular interest because the relationship between environmental factors and genetic alterations of carcinogenesis can be investigated. 1488746

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 AlteredExpression BEFREE These results suggest that p53 inactivation is not a necessary component of nasopharyngeal carcinogenesis in Cantonese but may be important in the establishment of cell lines derived from these tumors. 1511442

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 Biomarker BEFREE Based upon these results, we concluded that the p53 gene may play a role in the tumorigenesis of a limited number of parathyroid adenoma and thyroid cancers, and that the p53 mutation with an allelic loss of the p53 gene is an important factor in malignant tumorigenesis of the thyroid gland. 1516062

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE These results are consistent with the hypothesis that certain mutations in p53 may function in multistage lung carcinogenesis by reducing the responsiveness of bronchial epithelial cells to negative growth factors. 1557382

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Extremely frequent p53 gene mutations indicated that the mutations are likely be intimately involved in the carcinogenesis of oral squamous cell carcinoma. 1570156

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE Despite extensive data linking mutations in the p53 gene to human tumorigenesis, little is known about the cellular regulators and mediators of p53 function. 1614537

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.100 GeneticVariation BEFREE We conclude from this study that mutational or other alterations of the p53 gene are not common in nasopharyngeal carcinogenesis and that a codon-280 mutation of p53 may be involved in less than 10% of NPC cases. 1631151

1992