Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Constitutive expression of AID in the gastric mucosa of mice led to mutations in the human TP53, at amino acid coding positions identical to those detected in human gastric cancers. 24786892

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE HZ08 reverse the aneuploidy-induced cisplatin-resistance in Gastric cancer by modulating the p53 pathway. 24183976

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Artemisinin inhibits gastric cancer cell proliferation through upregulation of p53. 24078446

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE It didn't induce cell cycle arrest when AP-4 was knockdown in p53 defect gastric cancer cell line Kato-III. 22615908

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE HDAC3 is important to downregulate PUMA expression in gastric cancer and HDACis, like TSA, promoted PUMA expression through stabilizing p53 in addition to HDAC3 inhibition. 22763818

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Immunohistochemical staining of gastric cancer tissues from the same patient showed a high COP1 expression and a low p53 expression. 23091414

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. 23835407

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The aim of the present study was to evaluate the frequency of HER2-positive cases by application of the standard criteria in patients with resectable gastric cancer and to examine the relationships between HER2 expression and prognosis, mucin phenotype, p53 status, and clinicopathological features. 22410801

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy. 23423487

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Meta-analysis of the association between P53 codon 72 polymorphisms and gastric cancer. 22886602

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Thus, our results suggest that p53 gene therapy combined with chemotherapy represents a novel avenue for gastric cancer treatment. 22090785

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66).Age was a significant effect modifier. 22126203

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The mutation spectrum for ARID1A differs between molecular subtypes of gastric cancer, and mutation prevalence is negatively associated with mutations in TP53. 22037554

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 22675170

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child: evidence for chimerism involving a common mutant founder haplotype: case report. 22004116

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Pathway analysis demonstrated over-presentation of DNA damage response pathway and underscored critical roles of phosphorylated p53 in gastric cancer. 20953656

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE AJCC stage and P53 expression are independent prognostic factors in FGC patients. 21400534

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Early-onset gastric cancer seems to be a component of Li-Fraumeni syndrome, suggesting the need for early and regular endoscopic screening in individuals with germline TP53 mutations, particularly among those with a family history of gastric cancer. 21552135

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE This study identified some novel p53 mutations in gastric cancer and showed mutation pattern and frequency of p53 and k-ras in the population of the central southern region of China. 21080251

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Nutlin-3 showed potent antitumor activity against human gastric cancer cells with wt p53 and shows promise as a single agent and in combination with conventional anticancer drugs. 21205074

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Association of TP53 intron 3, 16 bp duplication polymorphism with esophageal and gastric cancer susceptibility in Kashmir Valley. 21473292

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE In the meta-analysis, TP53 72Pro was associated with increased risk of diffuse gastric cancer among Asians (OR, 1.44; 95% CI, 1.04-1.99), but decreased risk of intestinal gastric cancer among Caucasians (OR, 0.56; 95% CI, 0.36-0.89). 19536170

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Inhibition of the p53-MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer. 20020415

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE This study was designed to compare serum levels of p53 in a population characterized by high mortality due to stomach cancer and a high prevalence of H. pylori infection and another population in which mortality from this cause and the prevalence of H. pylori infection are low. 20525364

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The discrepancy between genetic polymorphism of p53 codon 72 and the expression of p53 protein in Helicobacter pylori-associated gastric cancer in Korea. 19184427

2010