Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE The developed array biochip is then utilized to parallelly analyze the O-GlcNAcylation of three oncogenic transcription factors C-Myc, NF-κB and p53 in normal prostate epithelial cell (RWPE-1) and prostate cancer cell line (PC-3). 30086259

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. 29617673

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE The present study aimed to investigate the expression of tumor protein p53 (p53), and its mechanism of function, in prostate cancer (PC). 29928424

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE The gain of MYCN and AURKA oncogenes, along with the loss of tumor suppressor genes TP53 and RB1 are key genomic alterations associated with treatment-related neuroendocrine prostate cancer. 29396873

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE Identical mutations were observed in prostate cancer driver genes (TP53, PTEN, FOXA1) in both single CTCs and cfDNA. 29762619

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE These findings highlight an important oncogenic aspect of USP10 through its modulation of the p53-G3BP2 complex and AR signaling in prostate cancer.<b>Implications:</b> These findings elucidate the oncogenic role of USP10 in prostate cancer through an increase in G3BP2 protein that inhibits p53 activity, in addition to the promotion of AR signaling.<i></i>. 29378906

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE Furthermore, immunostaining of p-STAT3 was increased in human prostate cancer specimens with EAF2 downregulation and/or p53 nuclear staining. 29518696

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE We observed that PCa cell lines that are TP53 wild-type, which includes cell lines derived from AAM (MDA-PCa-2b and RC77T), did not express detectable IL-6 mRNA. 29741809

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE The method was applied to the assay of p53 in human plasma sample and normal and malignant cell line lysates such as normal cell Line from mouse C3H (L929), colon cancer cell-HCT, prostate cancer cell line PC-3, and human breast adenocarcinoma cell line-MCF7. 29113888

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE Moreover, we find that elevated CD51 expression in PCa specimens correlates with p53 loss of function. 29743605

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Given that loss of p53 is associated with progression of prostate cancer to CRPC and NEPC, our results show that TET, by acting as a TRAIL-sensitizing agent in prostate cancer, could serve as a potential therapeutic agent in CRPC and NEPC, for which there is no cure to date.<i></i>. 29549167

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Although Ad-p53 gene therapy has yielded some interesting results when applied to prostate cancer, it has not been widely explored, perhaps due to current limitations of the approach. 30133562

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Thus, we concluded that p53 is a sensor for enhanced apoptosis in response to DNA damage stress, not DNA replication stress, at least in prostate cancer. 30198376

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status. 29499113

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE Thus, our findings show that overexpression of TRIM25 promoted prostate cancer cell proliferation and cell survival by modulating p53 nuclear export mechanism with G3BP2 interaction. 29379164

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Alterations affecting tumor suppressors and oncogenes, such as PTEN, MYC, BRCA2, and TP53, which have been long associated with aggressive PCa, demonstrated grade-dependent frequency of alterations in localized PCas. 30103901

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE The most prevalent mutations among patients with PC are c.1621A>C (rs3822214) in KIT, c.38G>C (rs112445441) in KRAS and c.733G>A (rs28934575) in TP53 genes. 29650325

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker CTD_human Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations. 29295717

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Also, the method was applied to the assay of p53 in human plasma sample and normal and malignant cell line lysates such as (L929 normal cell Line from mouse C3H (L929), colon cancer cell-HCT, prostate cancer cell line PC-3, and human breast adenocarcinoma cell line-MCF7). 28774804

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 GeneticVariation BEFREE The aim of this study was to assess the possible role of HPV in the development of prostate cancer (PCa) and investigate the distribution of the p53 codon 72 polymorphism in PCa in a Turkish population. 28124524

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. 28802253

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 AlteredExpression BEFREE Clinical studies demonstrate higher expression of NF-κB/p65/RelA, NF-κB/p50/RelB, and cRel as well as downregulation of the p53 network in primary prostate cancer specimens and in metastatic tumors. 28208611

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance. 28059767

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.500 Biomarker BEFREE The current study demonstrates that combination treatment blocks the cell cycle arrest by modulation of key regulators and promotes apoptosis via p53 dependent and independent mechanism in PCa. 28212547

2017