Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation BEFREE The Crohn's disease (CD) susceptibility gene, protein tyrosine phosphatase N2 (PTPN2), regulates interferon γ (IFNγ)-induced signalling and epithelial barrier function in T₈₄ intestinal epithelial cells (IECs). 21115548

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE IFN-γ was associated with the disease activity in UC, but did not reach significant level in CD. 21945121

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE In this study, we investigated the circulating IFN-γ and IL-12 production in 2 groups of Algerian patients with IBD (Crohn's disease and ulcerative colitis). 20626296

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Elevated levels of the pro-inflammatory cytokine, interferon-gamma (IFNgamma), are believed to be prominently involved in the pathogenesis of Crohn disease. 19654324

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression LHGDN Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. 18497880

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression LHGDN Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles. 18287963

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE The reason for the decreased frequency of an in vitro T(H)-cell IFNgamma response toward E. coli proteins in peripheral blood of CD and AS patients, e.g., increased suppression needs to be clarified. 19079222

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE The stimulatory effects of these cytokines on naive T cells in addition to a strongly synergistic action with IL-12 to trigger interferon-gamma production may contribute to the perpetuation of the inflammatory process in patients with CD. 15674109

2005

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE An increased expression of interleukin-18 (IL-18), a proinflammatory cytokine inducing interferon-gamma, has been found in Crohn's disease (CD). 16306764

2005

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE IL-2 and IFN-gamma were downregulated in PBMNC from CD and UC. 15827446

2005

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE Through the study of patients and mouse models, it has emerged that Crohn's disease is driven by the production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma), whereas ulcerative colitis is probably driven by the production of IL-13. 12876555

2003

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE It has recently been suggested that Crohn's Disease (CD) is associated with an exaggerated T helper 1 cytokine response as manifest by increased production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma). 11515847

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE Granzyme B mRNA levels correlated with interferon gamma mRNA levels in Crohn's disease. 10657017

2000

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation BEFREE We studied markers in the genes for NRAMP1 and two mutations in the interferon-gamma receptor in relation to inflammatory bowel disease (IBD) in the following groups: 270 healthy individuals, 74 patients with Crohn's disease, 72 patients with ulcerative colitis, and 40 patients with primary sclerosing cholangitis. 10207725

1999

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation BEFREE Intestinal and mesenteric lymph node samples from 9 children who had undergone ileal resection for CD were examined for the presence of epithelioid-giant cell granulomas (EGCG) and Rantes and IFN-gamma messenger RNA (mRNA). 9327364

1997

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression BEFREE The early ileal lesions of patients with CD were associated with a significant increase of IL-4 mRNA and a decrease of IFN-gamma mRNA compared with the normal mucosa of patients with CD or controls. 9207269

1997

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker BEFREE A sensitive reverse haemolytic plaque assay to detect lymphokine-secreting T cells, and Northern blot analysis to detect expression of lymphokine messenger RNA (mRNA) were used to study interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) production in the mucosa of children with Crohn's disease or ulcerative colitis (UC), and in histologically normal mucosa from patients without inflammatory bowel disease. 8436398

1993