Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury. 18666253

2008
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. 18227147

2008
Entrez Id: 5428
Gene Symbol: POLG
POLG
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1). 18208989

2008
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Therapeutic CTD_human Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. 18227147

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Therapeutic CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330

2007
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity. 17465707

2007
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. 16770646

2006
Entrez Id: 350
Gene Symbol: APOH
APOH
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. 16099942

2005
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human [Functional analysis of drug metabolizing enzymes using gene knockout animals]. 12875239

2003
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. 12668988

2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Therapeutic CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Therapeutic CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Biomarker CTD_human Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats. 145039

1977
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.400 Biomarker CTD_human Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study. 28043905

2017
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.400 Biomarker CTD_human Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. 21570397

2011
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.400 Biomarker CTD_human Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. 21570397

2011
Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357

2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. 30393195

2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. 30685357

2019
Entrez Id: 7100
Gene Symbol: TLR5
TLR5
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker CTD_human TLR5 silencing reduced hyperammonaemia-induced liver injury by inhibiting oxidative stress and inflammation responses via inactivating NF-κB and MAPK signals. 30508503

2019
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes. 30394310

2019