×
Entrez Id:
1555
Gene Symbol:
CYP2B6
CYP2B6
Drug-Induced Liver Disease
0.380
Biomarker
CTD_human
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.
28762043
2018
HLA-DRB1
Drug-Induced Liver Disease
0.370
Biomarker
CTD_human
The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1 *1501-DQB1*0602 that was previously associated with AC-DILI .
21570397
2011
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor.
30215777
2019
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1 β basal expression.
28138970
2017
×
Entrez Id:
8856
Gene Symbol:
NR1I2
NR1I2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.
28058446
2017
×
Entrez Id:
8856
Gene Symbol:
NR1I2
NR1I2
Drug-Induced Liver Disease
0.360
Biomarker
CTD_human
Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.
28058446
2017
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
Drug-Induced Liver Disease
0.360
Biomarker
CTD_human
Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1 β basal expression.
28138970
2017
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2.
26958860
2016
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Nrf2 protects against furosemide-induced hepatotoxicity.
24813929
2014
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation.
22627062
2012
×
Entrez Id:
4780
Gene Symbol:
NFE2L2
NFE2L2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
22491424
2012
×
Entrez Id:
8856
Gene Symbol:
NR1I2
NR1I2
Drug-Induced Liver Disease
0.360
Biomarker
CTD_human
Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.
19797606
2010
×
Entrez Id:
8856
Gene Symbol:
NR1I2
NR1I2
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.
19797606
2010
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
Drug-Induced Liver Disease
0.360
Therapeutic
CTD_human
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
19164858
2009
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
Drug-Induced Liver Disease
0.360
Biomarker
CTD_human
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
19164858
2009
×
Entrez Id:
1244
Gene Symbol:
ABCC2
ABCC2
Drug-Induced Liver Disease
0.360
Biomarker
CTD_human
Defining targets for investigating the pharmacogenomics of adverse drug reactions to antifungal agents.
18466103
2008
×
Entrez Id:
1244
Gene Symbol:
ABCC2
ABCC2
Drug-Induced Liver Disease
0.360
Biomarker
CTD_human
Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.
18381794
2008
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha.
21984482
2012
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Therapeutic
CTD_human
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha.
21984482
2012
×
Entrez Id:
2946
Gene Symbol:
GSTM2
GSTM2
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
20623750
2011
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Therapeutic
CTD_human
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
20623750
2011
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood.
20623750
2011
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
19638433
2009
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Therapeutic
CTD_human
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
19638433
2009
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
Drug-Induced Liver Disease
0.350
Biomarker
CTD_human
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
17709330
2007