Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.380 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.370 Biomarker CTD_human The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1*1501-DQB1*0602 that was previously associated with AC-DILI. 21570397

2011
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1β basal expression. 28138970

2017
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. 28058446

2017
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Biomarker CTD_human Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. 28058446

2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Biomarker CTD_human Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1β basal expression. 28138970

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. 26958860

2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. 22627062

2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. 22491424

2012
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Biomarker CTD_human Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid. 19797606

2010
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid. 19797606

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Therapeutic CTD_human Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. 19164858

2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Biomarker CTD_human Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. 19164858

2009
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Biomarker CTD_human Defining targets for investigating the pharmacogenomics of adverse drug reactions to antifungal agents. 18466103

2008
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.360 Biomarker CTD_human Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. 18381794

2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482

2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Therapeutic CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482

2012
Entrez Id: 2946
Gene Symbol: GSTM2
GSTM2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Therapeutic CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Therapeutic CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433

2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330

2007