Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE In xenografts models of PTEN-positive and PTEN-knock-in endometrial cancer, JQ1 significantly upregulated the expression of PTEN, blocked the PI3K/AKT signaling pathway and suppressed tumor growth. 27572308

2016

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. 25461816

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE These data suggest the impact of PTEN loss on tumor biology and clinical outcomes must be interpreted in the context of body mass index, and provide a potential explanation for discrepant reports on the effect of PTEN status and obesity on prognosis in endometrial cancer. 26045339

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE We also report that nuclear localization of FOXO1 correlated with PTEN mutational status irrespective of the PIK3CA status in endometrial cancer cell lines. 25698082

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Our data demonstrate that PTEN loss is detectable in endometrial tissues that are benign and malignant, with substantially more frequent loss in endometrial cancer compared with benign endometrium. 26376893

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Germline mutations in PTEN cause Cowden syndrome (CS), which increases lifetime risk of endometrial cancer. 26026735

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis, and, thus, could be an important mediator in the pathogenesis of endometrial cancer. 26511107

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Piwil1 causes epigenetic alteration of PTEN gene via upregulation of DNA methyltransferase in type I endometrial cancer. 26056945

2015

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Evaluation of expression of PTEN gene may turn out to be a very useful tool aimed at qualifying patients for different therapies of endometrial cancer and at searching of new diagnostic and therapeutic methods of this cancer independently on its receptor status nor maturity grade of cancer. 24030769

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells. 24929707

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE PTEN inactivation is the most frequent genetic aberration in endometrial cancer. 24625059

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Alterations in the PI3K pathway are prevalent in endometrial cancer due to PIK3CA mutation and loss of PTEN. 24561032

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 PosttranslationalModification BEFREE Rapid estrogen signaling negatively regulates PTEN activity through phosphorylation in endometrial cancer cells. 24844349

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Also, the PTEN gene has been shown to play an important role in endometrial cancer and glioblastoma, although the role of PTEN in MM has yet to be established. 24081673

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE However, the precise mechanism of PTEN/AKT signaling in endometrial cancer remains poorly understood. 25377472

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Loss of PTEN expression was common in both sporadic (69%) and LS-associated EC (86.2%). 23760948

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Activating mutations in FGFR2 have been identified as potential therapeutic targets in endometrial cancer, typically occurring alongside genetic alterations that disrupt the mTOR pathway, such as PTEN loss. 23468082

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE Expression of SCUBE2 gene declines in high grade endometrial cancer and associates with expression of steroid hormone receptors and tumor suppressor PTEN. 24053619

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE We genotyped a total of 48 potentially functional SNPs in 11 key genes (AKT1, AKT2, AKT3, BRAF, FRAP1, KRAS, PDPK1, PIK3CA, PIK3CB, PIK3R1, and PTEN) with the Sequenom genotyping platform in 115 endometrial cancer patients and 230 cancer-free women to evaluate their associations with risk, survival, and recurrence of endometrial cancer. 22146979

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE In the present study, we sought to determine whether PTENP1 is expressed in endometrial cancer (EMCA) cell lines and primary tumors along with the microRNAs (miRNAs) that are predicted to regulate PTEN and PTENP1 transcript levels. 22005521

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. 21984976

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 AlteredExpression BEFREE mTOR inhibition with temsirolimus has encouraging single-agent activity in endometrial cancer which is higher in chemotherapy-naive patients than in chemotherapy-treated patients and is independent of PTEN status. 21788564

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. 21468130

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 GeneticVariation BEFREE Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study. 21093899

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.600 Biomarker BEFREE New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes. 22586352

2011