Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression BEFREE In this study, we show that patients who develop prostate tumors with low levels of PTEN and high levels of HER2/3 have a poor prognosis. 21930937

2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells. 21456062

2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines. 20729295

2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression BEFREE Retroviral expression of constitutively active Notch-1 in human prostate tumor cell lines resulted in increased PTEN gene expression. 19479935

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. 19396168

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. 19116269

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 GeneticVariation BEFREE Alterations in the PIK3CA and PTEN genes were assessed in 40 prostate tumors (radical prostatectomy samples). 19443396

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN [Role of PTEN protein in multidrug resistance of prostate cancer cells]. 18702307

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision. 19081794

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Is PTEN loss associated with clinical outcome measures in human prostate cancer? 18854827

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 PosttranslationalModification LHGDN Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. 17606718

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN The role of PTEN in prostate cancer cell tropism to the bone micro-environment. 17347137

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human Integrative molecular concept modeling of prostate cancer progression. 17173048

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer. 17372210

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Pten inactivation and the emergence of androgen-independent prostate cancer. 17638861

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker BEFREE PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. 17826033

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. 17616684

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression BEFREE In the sc implanted human prostate tumors (22Rv-1) in nude mice, AN-7 significantly inhibited Ki-67, HIF-1alpha, HER-2/neu, bFGF and increased PTEN level. 17611019

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. 16697957

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker LHGDN Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. 16432235

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker CTD_human PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. 16421604

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker BEFREE Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is lost as a function of prostate tumor androgen dependence. 16637073

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Expression of mTOR signaling pathway markers in prostate cancer progression. 16652388

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression LHGDN Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors. 16496415

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 AlteredExpression BEFREE Significantly reduced PTEN expression was observed in AI versus benign and hormone naïve prostate tumors. 16496415

2006