|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Our results demonstrated that a novel small molecule selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes.
|
23250358 |
2013 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARγ on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
|
23426382 |
2013 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
At baseline, no differences were observed in NRF1-density between the T2DM men and the CON, while the contents of PGC1α and TFAM were decreased in the T2DM men.
|
23210442 |
2012 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The A-allele of the rs8192678 PGC-1 α} (G>A) gene variant has previously been associated with nephropathy in Korean and Indian-Asian type 2 diabetes mellitus (T2DM) samples.
|
22684233 |
2012 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
We conducted a meta-analysis to assess the association between three polymorphisms (Gly482Ser, Thr394Thr and Thr612Met) in PPARGC1A and T2DM.
|
21294239 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Patients with T2DM had significantly increased 8-OHdG and TUNEL labeling index and non-significant increases in the expression of PGC1-α and Tfam.
|
21281975 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes.
|
20175989 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Collectively, we propose FGFR1 in adipose tissues as a major functional receptor for FGF21, as an upstream regulator of PGC-1α, and as a compelling target for antibody-based therapy for type 2 diabetes and other obesity-associated disorders.
|
22174314 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
These data suggest that the PGC-1α Thr394Thr and Gly482Ser polymorphisms are associated with therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with type 2 diabetes mellitus.
|
20498286 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
We measured the metabolic parameters and the expression of PPARgamma and PGC-1alpha mRNA using quantitative real-time PCR in omental and subcutaneous (SC) adipose tissues in an observational study of 153 individuals as well as in SC fat and skeletal muscle in an interventional study of 60 subjects (20 each with normal glucose tolerance, impaired glucose tolerance, and T2D) before and after intensive physical training for 4 weeks.
|
19966034 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The objective of the study was to o investigate the relationship of the Gly482Ser (G482S) polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PPARGC1A) gene and type 2 diabetes mellitus (T2DM), obesity, and oxidative status in Chinese adults.
|
19913841 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
We investigated the effects of the common polymorphisms in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma; Pro12Ala) and in PPAR-gamma coactivator-1(PGC-1; Gly482Ser) genes on the response to pioglitazone in Chinese with type 2 diabetes mellitus.
|
20045142 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Patients with early-onset type 2 diabetes display abnormalities in the exercise-dependent pathway that regulates the expression of PGC-1alpha and Mfn2.
|
20032281 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker |
BEFREE |
Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D.
|
20410232 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Together, these results showed that PPARG Pro12Ala and PPARGC1A Gly482Ser variants are associated, alone and in interaction, with insulin and glucose homeostasis and suggest that gene-gene interactions should be taken into account in candidate gene studies of T2DM to identify subjects with markedly different risks of developing the disease.
|
19536736 |
2009 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The present study provides evidence that a common haplotype of PPARGC1A genetic polymorphisms are moderately associated with T2D in Han Chinese population.
|
19828207 |
2009 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension.
|
18614852 |
2008 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
PPARGC1A mRNA expression was reduced by 90% (p<0.005) and correlated with the reduction in insulin secretion in islets from patients with type 2 diabetes.
|
18270681 |
2008 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Two independent PPARGC1A variants associated significantly with type 2 diabetes (odds ratios [ORs] 1.35 and 2.46; P = 0.045 and <0.001).
|
18162502 |
2008 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
We did not find any significant association between three SNPs in the PGC-1alpha gene and T2DM in Hispanics or NHW; however, using FBAT, we found the common Thr612Thr allele of the PGC-1alpha gene to be associated with T2DM among Hispanic subjects carrying the rare Pro12Ala allele of the PPAR-gamma gene (p=.003).
|
17479445 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The objective of this case-control study was to explore the relationship between SNPs of PGC-1alpha and type 2 diabetes in the southern Chinese population and to determine whether the common variants: Gly482Ser and Thr394Thr, in the PGC-1alpha gene have any impacts on interaction with myocyte enhancer factor (MEF) 2C.
|
18067759 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus.
|
17310221 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
While expression of PGC-1alpha and many of its mitochondrial target genes are decreased in the skeletal muscle of patients with type 2 diabetes, no causal relationship between decreased PGC-1alpha expression and abnormal glucose metabolism has been established.
|
17932564 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression |
BEFREE |
Peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PPARGC1), a coactivator regulating the transcription of genes involved in oxidative metabolism, is downregulated in patients with type 2 diabetes and in their first-degree relatives.
|
16896940 |
2006 |