Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Proinflammatory genotypes of the IL-1 (interleukin-1) gene have been associated with an increased gastric cancer risk in Caucasians, whereas some studies in Asian populations did not find such association. 17596959

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The purpose of this study was to examine the association between IL-1 genotype and gastric cancer by systematically reviewing the risk of the original studies. 17096351

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE One hundred and forty-one non-cancer outpatients and 97 patients with gastric cancer were genotyped, and the relation between IL1B polymorphisms and gastric cancer was statistically analyzed. 17196954

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In contrast, among CagA negative subjects, no significant association of IL1B-31CC genotype with gastric cancer was observed. 16114018

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE No significant association of IL1B+3954T and gastric cancer risk was detected. 16985030

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE We tested the associations between polymorphisms of IL1B at positions -31, -511, and +3954 and the IL-1RN polymorphism [variable number of tandem repeats (VNTR) and TC polymorphism at the -2018 position] and GC in Omani Arab patients. 17235630

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Helicobacter pylori infection in combination with the serum pepsinogen I/II ratio and interleukin-1beta-511 polymorphisms are independent risk factors for gastric cancer in Thais. 17287896

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identified and treated. 17006981

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1beta and an increased risk of developing GC in a Korean population. 15551344

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Prognostic role of interleukin-1beta gene and interleukin-1 receptor antagonist gene polymorphisms in patients with advanced gastric cancer. 15800325

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE Variation in genes for cytokines such as interleukin-1beta and its receptor antagonist may allow identification of those individuals predisposed to mount an immune response that puts them at elevated risk for gastric cancer. 16103427

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Interleukin-1beta (IL-1beta) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylori infection. 16211343

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population. 15927855

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Polymorphisms in the interleukin 1beta gene (IL-1B-31T/C and IL-1B-511C/T single nucleotide changes) and in the interleukin 1 receptor anatagonist gene (IL-1RN2 variable number of tandem repeats) have been studied with respect to gastric cancer susceptibility. 15851404

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Interkeukin-1 (IL-1) gene cluster polymorphisms that are thought to enhance the production of IL-1beta are associated with an increased risk of gastric cancer. 16143884

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The aim of this study was to prospectively investigate the relationship between selected polymorphisms in three of the major IL-1 gene family members, seeking associations with H. pylori infection and/or gastric cancer. 15481335

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Also, IL-1beta genotype is one of the genetic markers of gastric cancer. 15658613

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE To elucidate the risks of host interleukin-1 (IL-1) genetic polymorphisms and H. pylori infection in the development of gastric cancer. 15233701

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Our results also suggest that the association between IL-1B polymorphism and an increased risk of gastric cancer may depend on the histologic type of gastric cancer. 15175940

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In advanced gastric cancer (tumor stages T2-T4), associations with polymorphisms of the interleukin-1 (IL-1) gene cluster have been made. 15570075

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer. 12530098

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE Polymorphisms of the IL-1B and IL-1RN genes (which encode interleukin [IL]-1beta and IL-1 receptor antagonist, respectively) have been associated with hypochlorhydria and gastric cancer. 12854083

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE The involvement of proinflammatory cytokines (especially IL-1 and IL-8) and reactive oxygen species (ROS) due to NF kappa B activation, increased cell proliferation combined with inhibition of apoptosis as well as upregulation of peroxisome proliferation activated receptor gamma (PPAR gamma) and inducible nitric oxide synthase (iNOS) appear to be major molecular biology alterations in pathogenesis of GC. 12883469

2003

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Interleukin-1 beta (IL-1beta) polymorphisms are associated with increased risk of gastric cancer in whites. 12105837

2002

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The most consistent results are the increased gastric cancer risk associated with IL1B and NAT1 variants, which may account for up to 48% of attributable risk of gastric cancer. 12115538

2002