Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms. 31601998

2020

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE By this study, a regulatory loop is proposed, wherein, ODC silencing in Y79 cells to result in decreased polyamine levels, thereby, leading to altered protein levels of Lin28b, MMP-2 and MMP-9, which falls in line with earlier studies in neuroblastoma. 29241071

2018

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE We also found that the combination of polymorphisms in CASC15, LIN28B, and LMO1 may be used to predict neuroblastoma risk (AUC=0.63, 95% CI=0.59-0.67). 29024823

2017

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE With the purpose to evaluate the association between LIN28B gene polymorphisms and neuroblastoma susceptibility in Southern Chinese population, we conducted this study with 256 neuroblastoma cases and 531 cancer-free controls. 27021521

2016

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 Biomarker BEFREE Here we show, however, that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. 27383785

2016

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. 26123663

2015

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE In vitro experiments using NB cell lines, BE(2)-C, SMS-KCNR, and CHLA90 show that DFMO treatment reduced LIN28B and MYCN protein levels and increased Let-7 miRNA and decreased neurosphere formation. 25415050

2015

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability. 25312269

2014

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals. 23222812

2013

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. 23042116

2012

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE The only common CNV across all tumors was 17q gain, with differing chromosomal coordinates across samples but a common region of overlap distal to 17q21.31, suggesting this adverse prognostic biomarker may offer insight about additional drivers for multifocal neuroblastoma in patients with germline PHOX2B or NF1 aberrations. 31515834

2020

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value. 31220430

2019

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE Interestingly, the forced expression of NR4A3 induced only the GAP43 but not the other molecules involved in NB cell differentiation, such as MYCN, TRKA, and PHOX2B. 31183633

2019

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE High levels of bone marrow TH and PHOX2B and of peripheral blood PHOX2B at diagnosis allow early identification of a group of high-risk infant and toddlers with neuroblastoma who may be candidates for alternative treatments. 29603574

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE Approximately 1-2% of neuroblastomas are inherited in an autosomal dominant fashion and a combination of co-morbidity and linkage studies has led to the identification of germline mutations in PHOX2B and ALK as the major genetic contributors to this familial neuroblastoma subset. 29589100

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE Given the central role of PHOX2B in the pathogenesis of CCHS, and the progesterone-mediated effects observed in the disease, we generated progesterone-responsive neuroblastoma cells, and evaluated the effects of 3-Ketodesogestrel (3-KDG), the biologically active metabolite of desogestrel, on the expression of PHOX2B and its target genes. 30036539

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE Phox2b immunohistochemistry (IHC) was performed on 159 paediatric tumours, including (group 1) 65 neural crest tumours with neuronal differentiation [peripheral neuroblastic tumours (pNT)]: 15 neuroblastoma undifferentiated (NB-UD), 10 NB poorly differentiated (NB-PD), 10 NB differentiating (NB-D), 10 ganglioneuroblastoma intermixed (GNBi), 10 GNB nodular (GNBn) and 10 ganglioneuroma (GN); (group 2) 23 neural crest tumours with neuroendocrine differentiation [pheochromocytoma/paraganglioma (PCC/PG)]; (group 3) 27 other neural crest tumours including one composite rhabdomyosarcoma/neuroblastoma; and (group 4) 44 non-neural crest tumours. 28986989

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE Mutation of PHOX2B and deletion of CIC in neuroblastoma cell lines induced activation of the RAS-MAPK pathway. 30115695

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE PHOX2B immunostain was performed on 29 paediatric cases, with adequate controls: one retroperitoneal embryonal tumour in a child with retinoblastoma (index 1), one posterior fossa embryonal tumour in a child with a neuroblastoma (index 2), seven medulloblastomas, four atypical teratoid/rhabdoid tumours (ATRT), four retinoblastomas, six pineoblastomas, four embryonal tumours with multilayered rosettes (ETMR) and two CNS embryonal tumours, not elsewhere classified. 29758594

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE The PHOX2B/TH expression in diagnostic BM of patients with neuroblastoma corresponded with a decreased survival rate (P < 0.001) in the total cohort and in different risk groups. 30007008

2018

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE We set out to determine whether the analysis of TH (tyrosine hydroxylase), PHOX2B (paired-like homeobox 2b), and DCX (doublecortin) transcripts using quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) could be used to detect NB contamination in ovarian tissue. 27734578

2017

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE Furthermore, it has been observed that neuronal differentiation in neuroblastoma is dependent on down-regulation of <i>PHOX2B</i> expression, which confirms that PHOX2B expression may be considered a target in neuroblastoma. 29069774

2017

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE PHOX2B is a highly sensitive and specific immunohistochemical marker for peripheral neuroblastic tumours, including neuroblastoma. 28640941

2017

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE Functional studies demonstrated dependency of neuroblastoma with noradrenergic identity on PHOX2B, evocative of lineage addiction. 28740262

2017