Source: GWASCAT

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. 27197191

2017

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. 25751625

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Similarly, rs17530068 at 6q14 was associated with breast cancer (OR = 1.12; P = 1.1 × 10(-9)), and with both ER-positive (OR = 1.09; P = 1.5 × 10(-5)) and ER-negative (OR = 1.16, P = 2.5 × 10(-7)) disease. 22976474

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT We performed in silico replication of 86 SNPs at P ≤ 1 × 10(-5) in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. 22976474

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). 22976474

2013

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 23535729

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). 22976474

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR = 1.16; P = 1.1 × 10(-8)) but showed a weaker association with overall breast cancer (OR = 1.08, P = 1.3 × 10(-6)) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR = 1.01, P = 0.67) based on 9965 cases and 22 902 controls. 22976474

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 GeneticVariation GWASCAT Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. 22976474

2013

Entrez Id: 4853
Gene Symbol: NOTCH2
NOTCH2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.660 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 5890
Gene Symbol: RAD51B
RAD51B
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 22891
Gene Symbol: ZNF365
ZNF365
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2018

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. 29058716

2017

Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191

2017

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191

2017

Entrez Id: 5890
Gene Symbol: RAD51B
RAD51B
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191

2017

Entrez Id: 8648
Gene Symbol: NCOA1
NCOA1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. 29058716

2017

Entrez Id: 27324
Gene Symbol: TOX3
TOX3
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.500 GeneticVariation GWASCAT This study indicated the role of TOX3 and FGFR2 as breast cancer susceptibility genes in BRCA1/2-wild-type breast cancer patients from Sardinian population. 25956309

2016