Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.540 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011
Entrez Id: 761
Gene Symbol: CA3
CA3
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.500 Biomarker CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249

2015
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam. 28844483

2017
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human "Serum microRNA signatures as ""liquid biopsies"" for interrogating hepatotoxic mechanisms and liver pathogenesis in human." 28545106

2017
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. 26489516

2015
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Recently, circulating microRNAs (miRNAs) such as miR-122 and miR-192 have emerged as promising biomarkers of liver injury in preclinical species and in DILI patients. 25359176

2015
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity. 25693865

2015
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human MiR-122 as a biomarker also has the potential to bridge results in in vitro experiments to in vivo animal models and human samples using the same assay, and to link findings from clinical studies in determining the relevance of in vitro models being developed for the study of drug-induced liver injury. 25527335

2015
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis. 22363424

2012
Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Circulating microRNAs as potential markers of human drug-induced liver injury. 22045675

2011
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. 21741958

2011
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure. 19481104

2009
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. 19483685

2009
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women. 18666253

2008
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity. 17465707

2007
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human In conclusion, slow acetylator status of NAT2 was a significant susceptibility risk factor for antituberculosis drug-induced hepatotoxicity; NAT2 genotyping may be a useful tool for predicting antituberculosis drug-induced hepatotoxicity. 17950035

2007
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota. 16799928

2006
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population. 16770646

2006
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. 12668988

2003
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. 11915035

2002
Entrez Id: 2875
Gene Symbol: GPT
GPT
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.400 Biomarker CTD_human Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats. 145039

1977
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.390 Biomarker CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513

2014
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.390 Biomarker CTD_human The GSTT1 homozygous null polymorphism may be a risk factor of antituberculosis drug-induced hepatotoxicity in Caucasians. 18397238

2008
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.390 Biomarker CTD_human The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women. 18666253

2008