Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.510 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.500 Biomarker CTD_human Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. 21741958

2011

Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.400 Biomarker CTD_human Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. 21570397

2011

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.370 Biomarker CTD_human Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity. 25693865

2016

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.370 Biomarker CTD_human Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. 17950035

2008

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.370 Biomarker CTD_human The aim of this study was to evaluate whether polymorphisms of the NAT2 and/or CYP2E1 genes were associated with antituberculosis drug-induced hepatotoxicity in Korean patients. 17950035

2008

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.370 Biomarker CTD_human In conclusion, slow acetylator status of NAT2 was a significant susceptibility risk factor for antituberculosis drug-induced hepatotoxicity; NAT2 genotyping may be a useful tool for predicting antituberculosis drug-induced hepatotoxicity. 17950035

2008

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.370 Biomarker CTD_human Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota. 16799928

2006

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.370 Biomarker CTD_human Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. 11915035

2002

Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.350 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.350 Biomarker CTD_human HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. 19483685

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.340 Biomarker CTD_human The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1*1501-DQB1*0602 that was previously associated with AC-DILI. 21570397

2011

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.340 Biomarker CTD_human The double-null genotype for GSTT1 and GSTM1 might play a role in determining the susceptibility to develop DILI, as a general mechanism that occurs regardless of the type of drug involved, and predominantly in women. 18666253

2008

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.340 Biomarker CTD_human Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury. 18666253

2008

Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.340 Biomarker CTD_human Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity. 17465707

2007

Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Biomarker CTD_human Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam. 28844483

2017

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Therapeutic CTD_human P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. 26958860

2017

Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Biomarker CTD_human Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human. 28545106

2017

Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Biomarker CTD_human Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. 26489516

2016

Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Biomarker CTD_human MiR-122 as a biomarker also has the potential to bridge results in in vitro experiments to in vivo animal models and human samples using the same assay, and to link findings from clinical studies in determining the relevance of in vitro models being developed for the study of drug-induced liver injury. 25527335

2015

Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Biomarker CTD_human Recently, circulating microRNAs (miRNAs) such as miR-122 and miR-192 have emerged as promising biomarkers of liver injury in preclinical species and in DILI patients. 25359176

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Therapeutic CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929

2014

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Therapeutic CTD_human Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. 22627062

2012

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Therapeutic CTD_human Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. 22491424

2012

Entrez Id: 406906
Gene Symbol: MIR122
MIR122
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.330 Biomarker CTD_human Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis. 22363424

2012