Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Prediction of drug-induced liver injury using keratinocytes. 28138970

2017

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Prediction of drug-induced liver injury using keratinocytes. 28138970

2017

Entrez Id: 7450
Gene Symbol: VWF
VWF
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Von Willebrand factor deficiency reduces liver fibrosis in mice. 28527913

2017

Entrez Id: 2936
Gene Symbol: GSR
GSR
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models. 28069987

2017

Entrez Id: 60
Gene Symbol: ACTB
ACTB
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249

2015

Entrez Id: 761
Gene Symbol: CA3
CA3
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249

2015

Entrez Id: 847
Gene Symbol: CAT
CAT
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249

2015

Entrez Id: 2936
Gene Symbol: GSR
GSR
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513

2014

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Urinary excretion of bilirubin oxidative metabolites in arsenite-treated mice. 22688006

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482

2012

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Urinary excretion of bilirubin oxidative metabolites in arsenite-treated mice. 22688006

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 847
Gene Symbol: CAT
CAT
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. 21741958

2011

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 5428
Gene Symbol: POLG
POLG
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. 20138553

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. 19164858

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433

2009

Entrez Id: 2729
Gene Symbol: GCLC
GCLC
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat. 19481141

2009

Entrez Id: 2875
Gene Symbol: GPT
GPT
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure. 19481104

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. 19164858

2009