Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 AlteredExpression BEFREE Neutrophils and peripheral blood mononuclear cells (PBMCs) were isolated from three patients diagnosed with RA and treated with various concentrations of IGU, methotrexate (MTX), or dexamethasone (DXM) or without any drugs as a control for 8 h. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 in culture supernatants were tested by ELISA. 31758423

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE Both Ang-1 and Ang-2 induced the production of IL-6, IL-12p40, IL-8 and CCL-3 in synovial tissue explants of RA and PsA patients, and Ang-2 neutralization suppressed the production of IL-6 and IL-8 in the synovial tissue of RA patients. 31377797

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE The innate gene expression signature (10 TLRs, 7 IL1/IL1R family members, and CXCL8/IL8) was assessed in peripheral blood mononuclear cells from RA patients (n=67), both with active (DAS28≥3.2, n=32) and inactive disease (DAS28<3.2, n=35), and in healthy control subjects (n=55). 31376255

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression BEFREE Unexpectedly, IL-12, IL-1β and CD163-, but not CD163+, cells induced IL-8 expression in colonic CD4+T cells, which co-expressed IFN-γ and/or IL-17 in UC and not CD. 31206576

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.400 AlteredExpression BEFREE Both miR-34c-5p agomir and CCL22 shRNA could reduce breathing frequency (f), airway resistance (RI), and the levels of IL-8 and TNF-α in BALF of COPD rats with increased Cydn (dynamic lung compliance) and PIF (peak inspiratory flow). 31032652

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.400 AlteredExpression BEFREE Our study found two hypomethylation-high-expression genes (CXCL3 and CXCL8) in COAD tissues compared with the adjacent normal tissues. 31709538

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.400 Biomarker BEFREE IL8 secretion is also implicated in prostate cancer progression and castration resistance. 31604846

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.400 Biomarker BEFREE Together, our results indicated that IL-8 triggered ovarian cancer cells migration partly through Wnt/β-catenin pathway mediated EMT, and IL-8 may be an important molecule in the invasion and metastasis of ovarian cancer. 31793192

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.400 Biomarker BEFREE Together, our results indicated that IL-8 triggered ovarian cancer cells migration partly through Wnt/β-catenin pathway mediated EMT, and IL-8 may be an important molecule in the invasion and metastasis of ovarian cancer. 31793192

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression BEFREE Overexpression of CPAP upregulates several STAT3 target genes such as IL-8 and CD44 that are involved in angiogenesis, and CPAP mRNA expression is positively correlated with the levels of both mRNAs in HCC. 31511651

2020

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 AlteredExpression BEFREE In this study, we found that high expression of IL-8 was positively associated with YY1 expression in RA. 30229869

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE • GAS5 and IL-8 were correlated in RA patients but not in healthy controls. 31372853

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE We compared therefore an innate gene signature of Toll-like receptors (TLRs), seven key members of the interleukin (IL)1/IL1R family, and CXCL8/IL8 in peripheral blood mononuclear cells from well-defined patients with active stages of RA (<i>n</i> = 36, DAS28 ≥ 3.2), SLE (<i>n</i> = 28, SLEDAI > 6), and SSc (<i>n</i> = 22, revised EUSTAR index > 2.25). 31396542

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 AlteredExpression BEFREE In addition, we found that the mRNA expression of IL-1β, IL-6, IL-8 and IL-17A were markedly down-regulated by treatment with betulinic acid in TNF-α-induced RA FLSs. 30553912

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 AlteredExpression BEFREE MiR-21 overexpression can repress the expressions of IL-6 and IL-8 and relieve the symptoms of RA by down-regulating the Wnt signal. 31389580

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE Also, the chemokines such as IP-10, RANTES and IL-8 as well as growth factors such as EGF, and VEGF were significantly (p<0.05) increased in RA. 29998825

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE When stimulated with FFA, osteoblasts from RA and OA patients secreted higher amounts of the proinflammatory cytokine interleukin (IL)-6 and the chemokines IL-8, growth-related oncogene α, and monocyte chemotactic protein 1. 31849953

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 GeneticVariation BEFREE For A23187-NETs, six NET proteins were higher in RA (<i>p</i> < 0.05), including CAMP/LL37, CRISP3, interleukin-8, MMP8; Thirteen proteins were higher in SLE, including histones H1.0, H2B, and H4. 30915077

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker BEFREE These results suggest that inhibition of RANKL induces the change in osteoclastogenesis-promoting factor from RANKL to IL-8, and FK506 may be a valuable combination drug to support the use of anti-RANKL Ab in treatment of RA. 30753461

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.400 Biomarker BEFREE IL-8 could act as a novel target for the treatment of BD theoretically and probably play a key role in disease recovery. 31695669

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 AlteredExpression BEFREE The objective of this study was to explore the clinical benefit of monitoring plasma IL-8 levels during breast cancer chemotherapy. 31029558

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE The results indicate that possible existence of positive feedback between IL8 and MMP9 might contribute to progression of breast cancer. 28730767

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 AlteredExpression BEFREE Interleukin-6 and interleukin-8 serum levels in prognosis of hormone-dependent breast cancer. 29482885

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE Lnc-SLC4A1-1 could promote the development of BC by regulating NF-κB/CXCL8. 31556319

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.400 Biomarker BEFREE The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells. 30788286

2019