Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE Additionally, ALDH2 is involved in the elimination of metabolites of neurotransmitters like 3,4-dihydroxyphenylacetaldehyde (DOPAL) and 3,4-dihydroxyphenylglycoaldehyde (DOPGAL) in the central nervous system (CNS).<b>Areas covered</b>: We examine the role of ALDH2 polymorphism in disease, aging and alcohol addiction and discuss its pharmacological targeting. 31697578

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE The low sensitivity in the present study suggests that a lack of alcohol flushing may play a crucial role in the development of alcohol dependence in women with inactive ALDH2. 30629674

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the ADH1B and ALDH2 genotypes in Japanese men with alcohol dependence. 31845443

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Our findings demonstrate that these variants, which were highly linked with ALDH2 rs671 and ADH1B rs1229984, were significant modulators for AD in our Han Chinese cohort. 31591379

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. 30852706

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE ALDH2*2 demonstrates its effect on alcohol consumption limiting and alcoholism developing protection, and this variant is recently found to have an important impact on human health. 31368107

2019

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE All 3 traits showed genomewide significant association with variants near ALDH2, with significance ranging from 2.01 × 10<sup>-14</sup> (for flushing; lead single nucleotide polymorphism (SNP) PTPN11* rs143894582) to p<sub>meta</sub>  = 5.80 × 10<sup>-10</sup> (for alcohol dependence criterion count; lead SNP rs149212747). 29460428

2018

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE Therefore, ALDH-2 inhibitors such as disulfiram represent the first therapeutic targeting of ALDH-2 for alcoholism therapy. 29431026

2018

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE We evaluated associations between the presence of fatty liver and ADH1B and ALDH2 genotypes and other factors in 1604 Japanese men who had been admitted for treatment of alcohol dependence. 29063269

2018

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454

2018

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE The ALDH2 gene was hypothesized to alter genetic susceptibility to alcohol dependence and alcohol-induced liver diseases. 29779728

2018

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE We find that disulfiram (Antabuse), an ALDH2 inhibitor in widespread clinical use for the treatment of alcoholism, selectively eliminates BRCA1/2-deficient cells. 28729482

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Individuals who are homozygous for polymorphism in ALDH2 tend to refrain from drinking alcohol, decreasing their chances of developing alcoholism and exposure to the associated risks. 28540979

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure. 27742538

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE Although prior studies reported effects of ADH1B and ALDH2 on lifetime measures, such as risk of alcohol dependence, our study adds further evidence of the effect of the same genes on a cross-sectional measure of average drinking. 28485404

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 AlteredExpression BEFREE These results suggest that gene therapy could be a useful tool for the treatment of alcoholism by knocking down ALDH2 expression using shRNA technology delivered by AAV vectors. 28578603

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. 28728635

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE We investigated the association between single nucleotide polymorphisms (SNPs) in ALDH2, which has been associated with alcohol dependence and several types of diseases, and the risk of drug addiction in a Chinese Han population. 28052001

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Our results describe a new regulatory role of rs886205 in the methylation of ALDH2 promoter region and provide additional insight into the complex regulation of ALDH2 under the condition of alcohol dependence. 28430929

2017

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 AlteredExpression BEFREE Reduced ALDH2 activity correlates with low alcohol tolerance and low risk for alcohol dependence. 26339786

2016

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE The enhanced AER in ADH1B*2 carriers and the increased sAcH levels in ALDH2*1/*2 carriers among intoxicated alcoholics provide possible mechanisms explaining how each genetic polymorphism affects the risk of alcoholism and upper aerodigestive tract cancer. 27087413

2016

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Certain genetic variants (i.e., alleles)--particularly the ADH1B*2, ADH1B*3, ADH1C*1, and ALDH2*2 alleles--have been associated with lower rates of alcohol dependence. 27163368

2016

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 GeneticVariation BEFREE Functional missense mutations in ADH1B and ALDH2 are protective against alcohol dependence. 27338962

2016

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE Genes in alcohol metabolism pathway, especially ADH1B and ALDH2, conferred the major genetic risk for AD in Taiwanese Han population. 26842247

2016

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.700 Biomarker BEFREE Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis. 26042511

2015