Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE Additionally, APOE polymorphic alleles that characterize impaired cerebrovascular integrity function as primary genetic determinants of AD. 31815697

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Associations between Aβ misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed. 31611055

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE One model was run for each AD risk factor, including: objectively-defined subtle cognitive decline (Obj-SCD), and genetic susceptibility [apolipoprotein E ε4 (APOE ε4) as well as cerebrospinal fluid β-amyloid (Aβ), total tau (tau), and hyperphosphorylated tau (p-tau). 31305320

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Our work suggests that CA may be a potential approach to attenuate the risk of ApoE4-associated AD. 31796678

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE The ɛ4 allele of apolipoprotein E (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease. 31489583

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE Susceptibility to AD is likely the result of complex interactions of the ε2 and ε4 alleles with other polymorphisms in the APOE region, and these interactions differ across races/ethnicities corroborating differences in the adverse and beneficial effects of the ε4 and ε2 alleles. 31813627

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE It has been reported that APOEɛ4, and not aggregated Aβ, contributes to glucose hypometabolism in pre-clinical stages of Alzheimer's disease (AD) pathology. 31796668

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE The lipid-binding protein apolipoprotein E (ApoE) has been found to interfere with Aβ amyloid formation and to exert a strong clinical impact to the pathology of AD. 31571352

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE Additionally, p-BTX-I alone increased the expression of apolipoprotein E (apoE) gene, associated with the proteolytic degradation of β-amyloid peptide aggregates, a hallmark of AD. 31654382

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Analysis implied that APOE ε4 might affect CSF YKL-40 levels in MCI subjects, suggesting a crucial role of APOE ε4 in neuroinflammation in detecting individuals who might convert to AD from MCI and, thus, as an effective predictive factor. 31794792

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE This study examined neuropsychological correlates of phonemic cueing benefit and the influential effects of AD severity, estimated premorbid intellectual functioning, and apolipoprotein E genotype status. 31030619

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE [PROVISIONAL] The combined risk effect among BIN1, CLU and APOE genes in Alzheimer's disease. 31469155

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease. 31791659

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE In addition, TADDZ corrected ASL MRI, with improved consistency, was shown to outperform conventional ASL MRI by differentiating the subtle CBF difference in Alzheimer's disease (AD) mice brains with different APOE genotypes. 31669538

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE The O-glycoprotein Apolipoprotein E (APOE), the strongest genetic risk factor for Alzheimer's disease, associates with lipoproteins. 31616924

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]). 31464095

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE These data indicated that the ApoE ε4 allele may also contribute to the pathogenesis of Alzheimer's disease through its effects on peripheral Aβ<sub>42</sub> and sLRP1 levels, but it needs to be further elucidated. 31350163

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Apolipoprotein E, lipoprotein(a), oxidized LDL (low density lipoprotein)'s and large LDL particles, as well as other proinflammatory lipids and stress hormones such as cortisol, have been recognized as key factors in amyloid plaque formation and aggravation of AD. 31595035

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE An upcoming phase 3 trial with ALZ-801 in APOE4/4 homozygous patients with early AD will effectively test this amyloid oligomer hypothesis. 31706733

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE To investigate the gene-environment interactions (GxE) between ApoE-ε4 and Cd exposure on cognition, we used a mouse model of Alzheimer's disease that expresses human ApoE-ε3 (ApoE3-KI (knock-in)) or ApoE-ε4 (ApoE4-KI). 31626305

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE Our findings suggest that the underlying mechanism of APOE polymorphism modulations on EM function and AD susceptibility is genetically related to the neural degeneracy of EM function across APOE alleles. 29396739

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Apolipoprotein E (APOE) is a prominent genetic risk factor for Alzheimer's disease (AD) and a frequent target for associations with non-demented and cognitively impaired aging. 30873923

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. 30465754

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Compared to APOEɛ4 non-carriers, APOEɛ4 carriers showed the opposite trajectory of DMN connectivity across the AD spectrum. 31282419

2019

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE We hypothesize that APOE4 influences all the pathological hallmarks of AD and may sit at the interface between neurodegeneration, inflammation and the spread of pathologies through the brain. 30394574

2019