Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 AlteredExpression BEFREE Our results demonstrate altered active IGF1 and IGF1R levels in AD hippocampi, and suggest that boosting brain expression of IGF1 may comprise an approach to prevent neuronal damage and memory loss in AD. 31760608

2020

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 AlteredExpression BEFREE These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression. 30867903

2019

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 Biomarker BEFREE Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer's Disease. 30809143

2019

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 AlteredExpression BEFREE Moreover, in Alzheimer's disease neurons, a high proportion of genes responding to Alzheimer's disease showed a reversed differential expression when IGF1R was deleted. 28595357

2017

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 AlteredExpression BEFREE But exclusively decreased IGF-1R expression reduces AD-associated mortality independent of β-amyloid accumulation and FoxO1-mediated transcription. 22057897

2013

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 Therapeutic RGD Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. 23562514

2013

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 Biomarker RGD While these disturbances were mostly corrected by restoring receptor function, blockade of the IGF-I receptor exacerbated AD-like pathology in old mutant mice already affected of brain amyloidosis and cognitive derangement. 16274856

2006

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 Biomarker CTD_human Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? 15750215

2005

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.560 Biomarker BEFREE Further studies demonstrated that: 1) ChAT expression increases with insulin or IGF-I stimulation; 2) ChAT is expressed in insulin and IGF-I receptor-positive cortical neurons; and 3) ChAT co-localization in insulin or IGF-I receptor-positive neurons is reduced in AD. 16340083

2005