Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE The characterization of CCR10<sup>+</sup> ILC2s in human samples and in mouse asthma models suggests that these cells downregulate allergic inflammation through IFN-γ production. 30475388

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE The significant increase of asthma incubation period, serum IFN-γ level were observed in the asthma guinea pigs treated with the active components group. 31531069

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE In this context, the IFN-γ levels were found enhanced in the BALF of Syringic acid treated asthmatic mice groups, expressing an anti-inflammatory response. 30474283

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of immunoglobulin E (IgE), interleukin-5 (IL-5), nerve growth factor (NGF) and interferon-γ (IFN-γ) in asthma allergy. 30359762

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE DFSCs decreased IL-4 and GATA3 expression and increased IFN-γ, T-bet and IL-10 expression in asthmatics. 29498435

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE The median BALF concentrations of IL-33, TSLP, IL-4, IL-5, IL-13, and IL-12p70, but not IL-25, IL-2, or IFN-γ, were significantly elevated in asthmatics compared with controls (<i>p</i> < 0.05). 29453280

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE In comparison with that in the healthy control (HC), significantly lower abundance of Bifidobacterium and lower levels of Th1 cytokines (IFN-γ and TNF-α), but higher levels of Th2-type cytokines (IL-4, IL-5) and Th17-type (IL-17A) cytokine were detected in children with bronchiolitis and asthma. 30290688

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-γ, TNF-α and IL-4 were strongly inhibited (p<0.001, p<0.001 and p<0.0094), compared to PMA treatment alone, for both, rhinitis and asthma. 30537802

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE The pooled data revealed that the proportion of children with fewer episodes of asthma was significantly higher in the probiotics group than in the control group (risk ratio 1.3, 95% confidence interval (CI) 1.06-1.59); the reduction of IL-4 (mean differences -2.34, 95% CI -3.38, -1.29) and the increasing of interferon-γ (mean differences 2.5, 95% CI 1.23-3.76) was also significant after the treatment of probiotics. 30051941

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE IFN-γ may participate in airway remodeling in asthma by regulating the expression of the ADAM33 gene. 28346792

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression. 29402723

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE Their Global Initiative for Asthma⁻based asthma severity, Childhood Asthma Control Test (C-ACT) scores, Pediatric Asthma Severity Scores, Pediatric Asthma Quality of Life Questionnaire scores, peak expiratory flow rates (PEFRs), medication use, the levels of immune biomarkers (immunoglobulin E (IgE), interferon γ, interleukin 4, and tumor necrosis factor α) at different visits, and the associated changes were evaluated. 30400588

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE Moreover, IL-17A/IL-10 and RORγt/Foxp3 ratios, but not IL-4/IFN-γ or GATA-3/T-bet ratios, negatively correlated with forced expiratory volume in the first second (FEV<sub>1</sub>)/FEV<sub>1pred</sub> and Asthma Control Test Questionnaire (ACT) scores in both exacerbation group and non-exacerbation group. 30233198

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE The frequency of MAIT cells was associated with increased production of IFN-γ by activated CD4<sup>+</sup> T cells from the URECA cohort. iNKT cell antigenic activity in bedroom dust samples was associated with higher endotoxin concentration and also with reduced risk of asthma. 29431692

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE C. pneumoniae-induced IFN-γ production in vitro was more prevalent in asthma compared with non-asthma; levels of IFN-γ were higher in asthma compared with non-asthma (P = 0.003). 28480606

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells. 27679954

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE Also, IFN-γ was found to be critical for increased airway hyperreactivity (AHR) in our model of SA. 28515358

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE The findings showed that the extract of <i>Z. multiflora</i> decreased pro-inflammatory cytokines in asthma (IL-4 and IL-17 and TGF-β) but increased anti-inflammatory cytokines (IFN-γ) gene expression and the number of Treg (FOXP3) in splenocytes of asthmatic mice which may indicate the specific therapeutic effect of the plant extract in allergy, autoimmunity, and infectious diseases via potentiating Th<sub>1</sub> and suppressing Th2 and Th<sub>17</sub> cells. 28824424

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE We show high levels of CXCL10 mRNA closely associated with IFNG levels in the BAL cells of 50% of severe asthmatics and also in the airways of mice subjected to a severe asthma model, both in the context of high-dose CS treatment. 28679952

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE However, while the 3 mg protein/ml SHE solution did not induce asthma, co-exposure with DEP resulted in a markedly enhanced AHR (p = 0.002) and eosinophilic inflammation (p = 0.004), with increased levels of IL-5, IL-17F and CCL20 and decreased levels of IFN-γ. 28628664

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE IFN-γ levels in asthma/A(H1N1)pdm09 mice at 3 days post-infection were higher than in all other mice at any time point, whereas at 7 days post-infection, the levels were lowest in asthma/A(H1N1)pdm09 mice. 28831046

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE This study at first demonstrated that the transplantation of TCs could improve allergen-induced asthma by obviously inhibiting airway inflammation and airway hyper-responsiveness preclinically, with the down-regulation of Th2-related cytokine IL-4, transcription factor GATA-3 and Th2 cell differentiation, while up-regulation of Th1-related cytokine IFN-γ, transcription factor T-bet and Th1 cells proliferation in asthma, just like MSCs. 28524369

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 AlteredExpression BEFREE Plasma IL-4 level was significantly higher in asthma exacerbation subjects than controls (157.98 ± 21.57 versus 121.92 ± 24.37 pg/mL; p < 0.0001), and IFN-γ level was significantly lower in asthma exacerbation subjects (292.73 ± 152.47 versus 421.78 ± 145.84 pg/mL; p = 0.0107). 26108069

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 Biomarker BEFREE High IFN-γ and low SLPI mark severe asthma in mice and humans. 26121748

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation BEFREE FcεRIβ -109C/T and IFN-γ 874T/A polymorphisms may be influencing factors for asthma in the Asian population. 25530133

2015