Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Association of Matrix Metalloproteinase 9 (<i>MMP-9</i>) Polymorphisms with Asthma Risk: A Meta-Analysis. 30931075

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE MMP-1 and MMP-9 expression was increased in the nasal tissues of smokers with asthma and CRS via real-time PCR and western blot. 31653934

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE AMs of asthma with a fast FEV<sub>1</sub> decline released a higher level of MMP-9 (8.52 ± 3.53 pg/mL, <i>p</i> < 0.05) than those of a slow FEV<sub>1</sub> decline (0.99 ± 0.20 pg/mL). 31547356

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE In addition, mediators or cytokines, including cysteinyl leukotrienes, matrix metallopeptidase-9, interleukin-33 and eosinophil expression of transforming growth factor-β, may contribute to airway remodeling in asthma. 31332973

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE The increase of oxidative stress and subsequent enhancement of MMP9 and TGF-<i>β</i>1 expression were rescued by the administration of Tetrandrine in the rat model of asthma. 31781316

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE Rutin also inhibited the expression of matrix metalloproteinase 9, thereby aiding in prevention of airway remodelling in asthma thereby revealing to be a potent candidate in asthma therapy. 30181695

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE The aim of this study was to investigate whether variants in 3' end of the MMP9 gene are associated with clinical phenotype and responsiveness to treatment in children with asthma. 29600353

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE Expression levels of ORMDL3, phosphorylated (p)‑ERK and MMP‑9 were significantly greater in the asthma‑model group; however, in the group pretreated with budesonide their expression was reduced. 28358425

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE There was no association between IL-6 and MMP-9 with asthma duration, total IgE, AEC, number of allergens sensitized and degree of sensitization. 27780376

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE We have found that MMP-9 concentration in breath condensates of children with stable asthma was slightly higher in ELISA, than in the activity assay. 27395373

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE This study indicates that CTGF upregulation correlates with MMP-9, probably involved in the pathogenesis of airway remodeling of asthma. 28507585

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD. 26123447

2016

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE Despite chronic treatment with inhaled steroids mean MMP-9/EBC activity in asthma group was significantly higher than in healthy controls. 25650123

2015

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE To investigate whether MMP-9 SNPs are associated with childhood-onset asthma in Mexican patients we conducted a case-control study including 403 children with clinical asthma diagnoses and 426 healthy controls from Mexico. 23639553

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model. 23244755

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE The results showed that the mean serum levels of MMP-9 in the children with asthma (136.53 ± 29.96 ng/ml) were significantly higher than that in the healthy controls (45.08 ± 12.53 ng/ml; P<0.05). 22052126

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE However, the role of the AP-1 sites within the MMP-9 promoter and the effect of commonly used asthma pharmacotherapies in modulating human rhinovirus (HRV)-induced MMP-9 production have not yet been elucidated. 22461694

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE Matrix metalloproteinase 9 (MMP9) gene has been shown to be involved in the pathogenesis of allergic rhinitis (AR) and asthma. 22237587

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE MMP-9 (gelatinase B) is recognized in chronic obstructive pulmonary disease (COPD) and now asthma as playing a central role in matrix degradation in injury, as well as contributing to the remodeling process. 21644819

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Genotyping of four HapMap derived tagging SNPs in the MMP-9 gene was performed using MALDI-TOF MS in three cross sectional study populations of German children (age 9-11; N = 4,264) phenotyped for asthma and atopic diseases according to ISAAC standard procedures. 20181264

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE Functionally, MMP-9-deficient mice had more acute allergic inflammation than wild-type mice, suggesting that MMP-9 was protective against experimentally induced asthma. 19667087

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE A disintegrin and metalloproteinase 33 (ADAM33) and matrix metalloproteinase-9 (MMP9) appear to have important roles in asthma and COPD pathogenesis. 17403951

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms. 16631427

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation LHGDN Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms. 16631427

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker LHGDN Levels of MMP-9 and TIMP-1 in BAL cell of asthmatic children were increased significantly at about 30- and 35-fold relative to the controls, respectively. 16754484

2006