Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE Based on the concept of immune dysregulation in immune thrombocytopenic purpura (ITP) and that Interleukin-18 (IL-18) is an inflammatory cytokine that plays an important role in autoimmune disease by inducing interferon-γ secretion; this study aimed to assess a possible association between the IL-18 promoter polymorphisms (-607 C/A site) and genetic susceptibility to ITP and the impact of the immunoglobulins (Igs) concentrations level on disease severity and response to therapy. 27600402

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE IFN-γ-producing T helper 1 (Th1) cell responses mediate protection against infections but uncontrolled Th1 activity also contributes to a broad range of autoimmune diseases. 28444759

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE IFN-γ(-/-) NOD.H-2h4 mice develop autoimmune disease with extensive hyperplasia and proliferation of thyroid epithelial cells (TEC H/P) and fibrosis. 27173733

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Our findings highlight a role for Mal outside the TLR system and imply that genetic variation in TIRAP may be linked to other IFN-γ-related diseases including autoimmunity and cancer. 26885859

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE The findings in our study suggest that STAT1 rs1467199 SNP plays a potential role in the IFN-γ dependent development of autoimmunity in children with ITP. 25707685

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE IFN-γ-producing Th17 cells have been implicated in autoimmune disorders, but their properties in humans are known only partially. 26520896

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Pathogenic functions of B cells in autoimmune diseases: IFN-γ production joins the criminal gang. 25727209

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines such as IL-1β and IFN-γ contributes to β-cell apoptosis. 24462878

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity. 25541140

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Our findings demonstrate the consequences of a chronic IFN-γ milieu on B220(+) cell types and in particular the impact of MZB cell loss on MZM function in autoimmunity. 24583068

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE Interferon-gamma (IFN-γ) is a paracrine inhibitor of melanocytes and genetic variability due to intron 1 polymorphisms in IFNG has been reported to be associated with increased risk for several autoimmune diseases. 23777204

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 AlteredExpression BEFREE (C-X-C motif) ligand (CXCL)10, an interferon-γ inducible Th1 chemokine, and its receptor, (C-X-C motif) receptor (CXCR)3, have an important role in different autoimmune diseases. 24529741

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Signal transducer and activator of transcription 4 (STAT4) transmits signals induced by interleukin-12, interleukin-23 and interferon-γ, which are key cytokines and play important roles in the development of autoimmune diseases. 23727609

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE In addition, the anti-apoptotic gene BCL3, interferon-γ (IFNG), and the vitamin D receptor (VDR) gene physically interact with significantly many genes that tend to be differentially expressed in PBMCs of patients with the analyzed autoimmune diseases. 23190644

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE A considerable proportion of reported cases of anti-IFN-γ autoantibodies show either clinical or laboratory evidence of autoimmune disease. 23243276

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Th cytokines IFN-γ and IL-17 are linked to the development of autoimmune disease. 23630349

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE A marked reduction of IL-2 was also observed for all CT relatives with autoimmunity and a lack of IFN-γ production was observed for the younger brother of the index patient, heterozygous for the polymorphism. 22809281

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-γ: potential therapeutic use in autoimmune diseases. 22424783

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 GeneticVariation BEFREE We conclude that a shift in immunodominance of self-antigenic determinants of Col-V results in induction of IFN-γ and IL-17 with loss of tolerance leading to autoimmunity to Col-V, which leads to chronic lung allograft rejection. 22132895

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE In contrast, inhibition of DP IV and APN activities selectively suppresses lymphocyte functions including proliferation and production of the T helper type (Th)1 cytokine IFN-γ, the Th17 cytokine IL-17, as well as TNF-α, and ameliorates autoimmunity in vivo. 21802166

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 AlteredExpression BEFREE The T-box transcription factor T-bet is a key regulator for the lineage commitment in CD4 Th1 cells and CD8 T cells by activating the hallmark production of interferon-γ, and its expression level is linked to autoimmune diseases. 20977921

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Interleukin-18 (IL-18), a pro-inflammatory cytokine with potent IFN-γ inducing activities, may play an important role in Th1-mediated autoimmune diseases. 20586818

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE Interferon-gamma is a potent Th1-type cytokine and a key molecule in the pathogenesis of autoimmune diseases including lupus nephritis. 20167631

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker BEFREE This analysis is integrated with the literature on the roles of IFNgamma in mediating a plethora of functions: anti-microbial responses, antigen processing, inflammation, growth suppression, cell death, tumor immunity and autoimmunity. 20036577

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.400 Biomarker CTD_human Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity. 19077085

2009