Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization. 28263967

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE Comprehensive genomic profiling of the patient's resected brain tumor revealed mutations in six genes: PTEN, VHL, MSH6, NOTCH1, RB1, and TP53. 28460341

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation CLINVAR Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients. 24721394

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 Biomarker BEFREE Collectively, these results: (1) suggest that PTEN status predicts sensitivity to 2ME2 and (2) justify exploration of 2ME2 combined with pan-PI3K inhibitors for the treatment of this intractable brain cancer. 24162827

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE Here, human brain tumor-initiating cell (BTIC) lines with different combinations of endogenous EGFR wild-type, EGFRvIII, and PTEN mutations were used to investigate response to the EGFR inhibitor gefitinib, mTORC1 inhibitor rapamycin, and dual mTORC1/2 inhibitor AZD8055 alone and in combination with temozolomide (TMZ) EXPERIMENTAL DESIGN: In vitro growth inhibition and cell death induced by gefitinib, rapamycin, AZD8055, and TMZ or combinations in human BTICs were assessed by alamarBlue, neurosphere, and Western blotting assays. 25316808

2014

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE AI at PTEN loci was found significantly more often in brain metastases (52%) and primary tumors with a brain relapse (59%) compared with primary tumors from patients without relapse (18%; P = 0.003) or relapse other than brain tumors (12%; P = 0.006). 22429330

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 Biomarker BEFREE Importantly, the activities of these TFs can be used to predict PTEN status in human prostate, breast and brain tumor samples with enhanced reliability when compared to straightforward IHC-based or expression-based analysis. 22347425

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 Biomarker BEFREE Here we review recent progress from brain tumor and intestinal stem cell research with a focus on the PTEN-Akt-Wnt pathway, and how the components of CSC pathways may serve as biomarkers for diagnosis, prognosis, and therapeutics. 19442199

2009

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 Biomarker BEFREE Inactivation of the tumor suppressor phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) is recognized as a major event in the pathogenesis of the brain tumor glioblastoma. 18524891

2008

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 AlteredExpression LHGDN Relationship between PTEN gene expression and differentiation of human glioma. 17000554

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE The tumor suppressor gene PTEN, mutated in 40-50% of patients with brain tumors, especially those with glioblastomas, maps to chromosome 10q23.3 and encodes a dual-specificity phosphatase. 16619521

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE Patients with loss of wildtype PTEN expression from one allele carry an increased risk of malignant breast, thyroid and brain tumors. 16964417

2006

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 Biomarker BEFREE Chromosome 10q contains at least 2 tumor suppressor genes that might play a role in brain tumor development: PTEN and DMBT1. 15547761

2004

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE Together, these findings suggest that the Arg234Gln missense mutation in PTEN has oncogenic properties and predisposes to brain tumours of multiple lineages. 12085208

2002

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation LHGDN Together, these findings suggest that the Arg234Gln missense mutation in PTEN has oncogenic properties and predisposes to brain tumours of multiple lineages. 12085208

2002

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 Biomarker BEFREE PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase (FAK). 11479198

2001

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation CLINVAR PTEN controls tumor-induced angiogenesis. 11274365

2001

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE We screened mutations of two major tumor suppressor genes, p53 and PTEN, in 66 human brain tumors using a yeast-based functional assay and cDNA-based direct sequencing, respectively. 11051241

2000

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 GeneticVariation BEFREE No evidence for germline PTEN mutations in families with breast and brain tumours. 10371336

1999

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms
0.500 CausalMutation CGI